ArticleeLife2021
Distributed coding of duration in rodent prefrontal cortex during time reproduction.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Dissociable cortical contributions to impulse control during waiting.Science advances · 2025Article
- Amphetamine increases timing variability by degrading prefrontal temporal encoding.Neuropharmacology · 2025Article
- Learning Temporal Relationships Between Symbols with Laplace Neural Manifolds.Computational brain & behavior · 2025Article
- Stable sequential dynamics in prefrontal cortex represents subjective estimation of time.eLife · 2024Article
- Ramping cells in the rodent medial prefrontal cortex encode time to past and future events via real Laplace transform.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Neuroimaging Signatures of Metacognitive Improvement in Sensorimotor Timing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Ramping cells in rodent mPFC encode time to past and future events via real Laplace transform.bioRxiv : the preprint server for biology · 2024Article
- A Second Introduction to the Neurobiology of Interval Timing.Advances in experimental medicine and biology · 2024Review
- Naturalistic neuroscience and virtual reality.Frontiers in systems neuroscience · 2022Review
- A virtual reality time reproduction task for rodents.Frontiers in behavioral neuroscience · 2022Article
- Article
- A precise and adaptive neural mechanism for predictive temporal processing in the frontal cortex.Neuron · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As we interact with the external world, we judge magnitudes from sensory information. The estimation of magnitudes has been characterized in primates, yet it is largely unexplored in nonprimate species. Here, we use time interval reproduction to study rodent behavior and its neural correlates in the context of magnitude estimation. We show that gerbils display primate-like magnitude estimation characteristics in time reproduction. Most prominently their behavioral responses show a systematic overestimation of small stimuli and an underestimation of large stimuli, often referred to as regression effect. We investigated the underlying neural mechanisms by recording from medial prefrontal cortex and show that the majority of neurons respond either during the measurement or the reproduction of a time interval. Cells that are active during both phases display distinct response patterns. We categorize the neural responses into multiple types and demonstrate that only populations with mixed responses can encode the bias of the regression effect. These results help unveil the organizing neural principles of time reproduction and perhaps magnitude estimation in general.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.