Trial reportDeutsches Arzteblatt international2021
Reduction of Potentially Inappropriate Medication in the Elderly.
Trial report in Deutsches Arzteblatt international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Optimizing Medication Use in Older Adults in Primary Care: A Systematic Review of the Effectiveness of Deprescribing Interventions.Geriatrics & gerontology international · 2026Pooled it
- Interventions to Address Potentially Inappropriate Prescribing for Older Primary Care Patients: A Systematic Review and Meta-Analysis.JAMA network open · 2025Pooled it
- Deprescribing in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.JAMA network open · 2025Pooled it
- Interventions to improve the appropriate use of polypharmacy for older people.The Cochrane database of systematic reviews · 2023Pooled it
- Longitudinal Non-interventional Changes of the FORTA Score are Associated with Changes of Cognitive and Physical Function Tests in Community-Dwelling Older People.Drugs & aging · 2026Article
- Enhancing Continuous Medication Safety Through e-Prescription and Clinical Decision Support Systems in Outpatient Practices and Pharmacies: Protocol for a Multiperspective Study (eRIKA Study).JMIR research protocols · 2026Article
- Clinical-Pharmacological Drug Information Center of Hannover Medical School: Update From a Tertiary Care University Hospital (2022-2024).Pharmacology research & perspectives · 2026Article
- [Concepts to improve medication safety in older patients].Innere Medizin (Heidelberg, Germany) · 2026Review
- [Why represcribing instead of deprescribing?]Innere Medizin (Heidelberg, Germany) · 2026Article
- General practitioner-pharmacist collaboration to enhance deprescribing of psychotropics, sedatives, and anticholinergics among older polypharmacy patients in primary care: study protocol of a cluster-randomized controlled trial (PARTNER).Therapeutic advances in drug safety · 2026Article
- Education about deprescribing for pre-licensed and licensed healthcare professionals: A scoping review.British journal of clinical pharmacology · 2025Article
- Education about deprescribing for pre-licensed and licensed healthcare professionals: A scoping review.British journal of clinical pharmacology · 2025Article
- Validation of MyFORTA: An Automated Tool to Improve Medications in Older People Based on the FORTA List.Drugs & aging · 2024Article
- [Safe discontinuation of psychotropic drugs in older people? : New evidence and practical approach].Der Nervenarzt · 2024Review
- [Safe discontinuation of psychotropic drugs in older people? : New evidence and practical approach].Zeitschrift fur Gerontologie und Geriatrie · 2023Review
- Potentially inappropriate medication including drug-drug interaction and the risk of frequent falling, hospital admission, and death in older adults - results of a large cohort study (getABI).Frontiers in pharmacology · 2023Article
- Clinical-pharmacological drug information center of Hannover Medical School: experiences and analysis from a tertiary care university hospital.Scientific reports · 2022Article
- Prescribing Cascades: How to Detect Them, Prevent Them, and Use Them Appropriately.Deutsches Arzteblatt international · 2022Review
- Reduction of potentially inappropriate medication in the elderly.Deutsches Arzteblatt international · 2022Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMedications with an unfavorable risk-benefit profile in the elderly, and for which there are safer alternatives, are designated as potentially inappropriate medications (PIM). The RIME trial (Reduction of Potentially Inappropriate Medication in the Elderly) was based on PRISCUS, a list of PIM that was developed in 2010 for the German pharmaceuticals market. In this trial, it was studied whether special training and the PRISCUS card could lessen PIM and undesired drug-drug interactions (DDI) among elderly patients in primary care.
methodsA three-armed, cluster-randomized, controlled trial was carried out in two regions of Germany. 137 primary care practices were randomized in equal numbers to one of two intervention groups-in which either the primary care physicians alone or the entire practice team received special training-or to a control group with general instructions about medication. The primary endpoint was the percentage of patients with at least one PIM or DDI (PIM/DDI) per practice. The primary hypothesis was that at 1 year this endpoint would be more effectively lowered in the intervention groups compared to the control group.
resultsAmong 1138 patients regularly taking more than five drugs, 453 (39.8%) had at least one PIM/DDI at the beginning of the trial. The percent - ages of PIM/DDI at the beginning of the trial and 1 year later were 43.0% and 41.3% in the intervention groups and 37.0% and 37.6% in the control group. The estimated intervention effect of any intervention (69 practices) versus control (68 practices) was 2.3% (p = 0.36), while that of team training (35 practices) versus physician training (34 practices) was 4.3% (p = 0.22).
conclusionThe interventions in the RIME trial did not significantly lower the percentage of patients with PIM or DDI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.