ArticleThe Journal of international medical research2021
Predictive value of hemoglobin, platelets, and D-dimer for the survival of patients with stage IA1 to IIA2 cervical cancer: a retrospective study.
Article in The Journal of international medical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Preoperative non-invasive prediction of lymph node metastasis in cervical cancer using a multiparametric radiomics model based on transvaginal ultrasound.Abdominal radiology (New York) · 2026Article
- The value of tertiary lymphoid structure on predicting the survival rate of advanced cervical cancer patients.BMC cancer · 2026Article
- High preoperative D-dimer increases the risk of venous thromboembolism after gynecological tumor surgeries: a meta-analysis of cohort studies.Research and practice in thrombosis and haemostasis · 2025Review
- Evaluation of treatment for diffuse large B-cell lymphoma using plasma D-dimer levels.Scientific reports · 2025Article
- Increased levels of regulatory T cells and IL-10-producing regulatory B cells are linked to improved clinical outcome in Parkinson's disease: a 1-year observational study.Journal of neural transmission (Vienna, Austria : 1996) · 2024Observational
- Potential clinical utility of plasma D-dimer levels among women with cervical cancer in Lagos, Nigeria.Ecancermedicalscience · 2023Article
- Article
- Heat-shock protein 90α is a potential prognostic and predictive biomarker in hepatocellular carcinoma: a large-scale and multicenter study.Hepatology international · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCoagulation indexes may be useful survival biomarkers for cervical cancer. This study evaluated the ability of hemoglobin, red blood cells (RBCs), platelets, and D-dimer levels to predict post-hysterectomy survival outcomes in patients with stage IA1 to IIA2 cervical cancer.
methodsIn this retrospective study, coagulation-related indexes were compared between the anemia and non-anemia groups. Independent variables were analyzed by the Cox proportional hazards model. Survival was assessed by the Kaplan-Meier method with the log-rank test. Mortality predictions were evaluated by receiver operating characteristic curves.
resultsAmong this study's 1088 enrolled patients, 152 had anemia. The 10-year overall survival and recurrence-free survival rates were 90.8% and 86.5%, respectively. Hemoglobin, RBC, and the rate of abnormal platelet counts were significantly lower in the anemia group. Abnormal preoperative D-dimer was an independent factor for recurrence-free survival. Receiver operating characteristic curves showed that D-dimer had area under the curve of 0.734 (cut-off value: 0.685, sensitivity: 85.7%, and specificity: 64.0%). Hemoglobin and platelets had areas under the curves of 0.487 and 0.462, respectively.
conclusionPreoperative D-dimer was the most effective prognostic predictor for patients with cervical cancer. The prognosis of patients with cervical cancer was poorer if their D-dimer levels were >0.685 mg/L.
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