Evidence map›Paper›PMID 34939783›Full record

ArticleAnalytical chemistry2022

Single-Walled Carbon Nanotube Probes for the Characterization of Biofilm-Degrading Enzymes Demonstrated against

Sparsh Agarwal, Nathaniel E Kallmyer, Dua X Vang, Alma V Ramirez, Md Monirul Islam, Andrew C Hillier, Larry J Halverson, Nigel F Reuel

Open access · greenAbstract read
In one paragraph

Article in Analytical chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Near-Infrared Fluorescent Single-Walled Carbon Nanotubes for Biosensing.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sparsh AgarwalDepartment of Chemical and Biological Engineering, Iowa State University, Ames, Iowa 50011, United States.
Nathaniel E KallmyerDepartment of Chemical and Biological Engineering, Iowa State University, Ames, Iowa 50011, United States.
Dua X VangDepartment of Plant Pathology and Microbiology, Iowa State University, Ames, Iowa 50011, United States.
Alma V RamirezDepartment of Chemical and Biological Engineering, Iowa State University, Ames, Iowa 50011, United States.
Md Monirul IslamDepartment of Chemical and Biological Engineering, Iowa State University, Ames, Iowa 50011, United States.
Andrew C HillierDepartment of Chemical and Biological Engineering, Iowa State University, Ames, Iowa 50011, United States.ORCID 0000-0002-2729-1368
Larry J HalversonDepartment of Plant Pathology and Microbiology, Iowa State University, Ames, Iowa 50011, United States.
Nigel F ReuelDepartment of Chemical and Biological Engineering, Iowa State University, Ames, Iowa 50011, United States.ORCID 0000-0003-3438-2919
Iowa State University · US

Funding

Unsupervised optimization of protein therapeutics using closed-loop in vitro synthesis, nanosensing,and deep-learningR35GM138265 · NIGMS · IOWA STATE UNIVERSITY · PI Nigel F Reuel · 2020 to 2026
$2.3M
NIGMS NIH HHS R35 GM138265
6 · The paper itself

Abstract

Hydrolase co-therapies that degrade biofilm extracellular polymeric substances (EPS) allow for a better diffusion of antibiotics and more effective treatment; current methods for quantitatively measuring the enzymatic degradation of EPS are not amendable to high-throughput screening. Herein, we present biofilm EPS-functionalized single-walled carbon nanotube (SWCNT) probes for rapid screening of hydrolytic enzyme selectivity and activity on EPS. The extent of biofilm EPS degradation is quantified by monitoring the quenching of the SWCNT fluorescence. We used this platform to screen 16 hydrolases with varying bond breaking selectivity against a panel of wild-type

Indexed as

Nanotubes, CarbonPseudomonas aeruginosaAnti-Bacterial AgentsBiofilmsExtracellular MatrixAnti-Bacterial AgentsNanotubes, Carbon

Identifiers

PMID34939783
PMCPMC9150823
OpenAlexW4200337607

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.