Evidence map›Paper›PMID 34939781›Full record

ArticleACS synthetic biology2022

A Tunable and Expandable Transactivation System in Probiotic Yeast

Suryang Kwak, Bejan Mahmud, Gautam Dantas

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS synthetic biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Antibiotic perturbations to the gut microbiome.Nature reviews. Microbiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Suryang KwakThe Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.ORCID 0000-0002-5202-8326
Bejan MahmudThe Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Gautam DantasThe Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.ORCID 0000-0003-0455-8370
Washington University in St. Louis · US

Funding

Impact of early-life perturbations on pediatric microbiome maturationR01AI155893 · NIAID · WASHINGTON UNIVERSITY · PI Gautam Dantas · 2021 to 2026
$4.6M
Tunable therapeutic modulation of the gut microbiome by engineered probioticsR01AT009741 · NCCIH · WASHINGTON UNIVERSITY · PI DANTAS, GAUTAM, MOON, TAE SEOK · 2018 to 2022
$3.5M
NCCIH NIH HHS R01 AT009741NIAID NIH HHS R01 AI155893
6 · The paper itself

Abstract

Precise transcriptional modulation is a key requirement for developing synthetic probiotics with predictably tunable functionalities. In this study, an expandable and tunable transactivation system was constructed and validated in probiotic yeast

Indexed as

ProbioticsSaccharomyces boulardiiPromoter Regions, GeneticSaccharomyces cerevisiaeTranscriptional ActivationCas9Saccharomyces boulardiiscaffold RNAtransactivation

Identifiers

PMID34939781
PMCPMC9013468
OpenAlexW4200302760

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.