Evidence map›Paper›PMID 34939724›Full record

ArticleJournal of intellectual disability research : JIDR2022

Co-occurring medical and behavioural conditions in children with Down syndrome with or without ADHD symptom presentation.

A J Esbensen, L B Vincent, J N Epstein, K Kamimura-Nishimura, S Wiley, K Angkustsiri, L Abbeduto, D Fidler, J S Anixt, T E Froehlich

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of intellectual disability research : JIDR, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

A J EsbensenDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID 0000-0003-2649-7791
L B VincentSchool of Human Services, University of Cincinnati, Cincinnati, OH, USA.
J N EpsteinDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
K Kamimura-NishimuraDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
S WileyDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
K AngkustsiriMIND Institute, University of California, Davis, Davis, CA, USA.
L AbbedutoMIND Institute, University of California, Davis, Davis, CA, USA.
D FidlerDepartment of Human Development and Family Studies, Colorado State University, Fort Collins, CO, USA.
J S AnixtDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
T E FroehlichDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Cincinnati Children's Hospital Medical Center · USUniversity of California, Davis · USColorado State University · USUniversity of Cincinnati · US

Funding

INCLUDE19 – Evaluating outcome measures in young adults with Down syndromeR01HD093754 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI Anna J. Esbensen · 2018 to 2026
$6.2M
Evaluating Assessment and Medication Treatment of ADHD in Children with Down SyndromeR33HD100934 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI ESBENSEN, ANNA J., FROEHLICH, TANYA E. · 2022 to 2024
$4.2M
Evaluating Assessment and Medication Treatment of ADHD in Children with Down SyndromeR61HD100934 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI ESBENSEN, ANNA J., FROEHLICH, TANYA E. · 2019 to 2021
$1.5M
Treatment of sleep disturbances in school-age children with Down syndromeR21HD082307 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI ESBENSEN, ANNA J. · 2015 to 2016
$427k
NICHD NIH HHS R01 HD093754NICHD NIH HHS R21 HD082307NICHD NIH HHS R33 HD100934NICHD NIH HHS R61 HD100934
6 · The paper itself

Abstract

backgroundCo-occurring attention deficit hyperactivity disorder (ADHD) is a challenge to characterise in the presence of other medical conditions commonly present in children with Down syndrome (DS). The current study examined differences among children with DS with or without ADHD symptomatology in terms of demographics, developmental level, co-occurring medical conditions, and parent and teacher ratings of behaviour and executive functioning.

methodsParents and teachers of 108 school-age children with DS provided ratings of ADHD symptoms, behaviour problems and executive functioning skills. Children with DS and ADHD symptom presentation, as identified by a scoring algorithm, were compared with those without ADHD symptom presentation on demographic characteristics, developmental level, co-occurring medical conditions and parent-report and teacher-report measures of behaviours and executive functioning.

resultsSleep disorders, disruptive behaviour disorder, allergies and seizures were more common in children with DS and ADHD symptom presentation than in children without ADHD symptom presentation. After controlling for ADHD medication use, children with DS and ADHD symptom presentation had poorer performance than those without ADHD symptom presentation on parent behaviour ratings, teacher behaviour ratings and parent but not teacher ratings of executive functioning. No significant group differences in demographic characteristics or developmental level were identified.

conclusionsHigher rates of co-occurring medical conditions present in children with DS and ADHD symptom presentation support the need for thorough differential diagnoses. The different pattern of group differences between parent-report and teacher-report has implications for diagnostic practices across settings as well as for treatment.

Indexed as

Attention Deficit Disorder with HyperactivityDown SyndromeProblem BehaviorAttention Deficit and Disruptive Behavior DisordersChildHumansParentsADHDBehaviourCo-occurring medical conditionsDown syndromeSymptomsTrisomy 21

Identifiers

PMID34939724
PMCPMC8816818
OpenAlexW4200018542

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.