Evidence map›Paper›PMID 34939369›Full record

ArticleAdvanced biology2022

Biodistribution of Biomimetic Drug Carriers, Mononuclear Cells, and Extracellular Vesicles, in Nonhuman Primates.

Matthew J Haney, Hong Yuan, Steven T Shipley, Zhanhong Wu, Yuling Zhao, Kelly Pate, Jonathan E Frank, Nicole Massoud, Paul W Stewart, Joel S Perlmutter and 1 more

Abstract read
In one paragraph

Article in Advanced biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Engineered EVs designed to target diseases of the CNS.Journal of controlled release : official journal of the Controlled Release Society · 2023
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Matthew J HaneyCenter for NanotechFnology in Drug Delivery, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Hong YuanDepartment of Radiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA.
Steven T ShipleyDivision of Comparative Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Zhanhong WuDepartment of Radiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA.
Yuling ZhaoCenter for NanotechFnology in Drug Delivery, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Kelly PateDivision of Comparative Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA.
Jonathan E FrankDepartment of Radiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA.
Nicole MassoudDivision of Comparative Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Paul W StewartDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Joel S PerlmutterSchool of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Elena V BatrakovaCenter for NanotechFnology in Drug Delivery, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID 0000-0002-9386-3790

Funding

Cell-based Platform for Gene Delivery to the BrainR01NS102412 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BATRAKOVA, ELENA · 2018 to 2022
$1.7M
Extracellular Vesicles for CNS Delivery of Therapeutic Enzymes to Treat Lysosomal Storage DisordersR01NS112019 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BATRAKOVA, ELENA · 2019 to 2023
$1.5M
NINDS NIH HHS R01 NS102412NINDS NIH HHS R01 NS112019
6 · The paper itself

Abstract

Discovery of novel drug delivery systems to the brain remains a key task for successful treatment of neurodegenerative disorders. Herein, the biodistribution of immunocyte-based carriers, peripheral blood mononuclear cells (PBMCs), and monocyte-derived EVs are investigated in adult rhesus macaques using longitudinal PET/MRI imaging.

Indexed as

Drug CarriersExtracellular VesiclesAnimalsBiomimeticsLeukocytes, MononuclearMacaca mulattaPositron Emission Tomography Computed TomographyTissue DistributionDrug Carriersbrain bioavailabilitydrug delivery systemextracellular vesiclesmonocytesnonhuman primates

Identifiers

PMID34939369
PMCPMC8825682

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.