Evidence map›Paper›PMID 34939367›Full record

ArticleJournal of cachexia, sarcopenia and muscle2022

Histomorphological and inflammatory changes of white adipose tissue in gastrointestinal cancer patients with and without cachexia.

Alessio Molfino, Raffaella Carletti, Giovanni Imbimbo, Maria Ida Amabile, Roberta Belli, Cira R T di Gioia, Elena Belloni, Francesco Spinelli, Veronica Rizzo, Carlo Catalano and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. The effects of tissue inflammation on cancer cachexia.Biochimica et biophysica acta. Molecular basis of disease · 2026
    Review
  4. Cancer cachexia: molecular basis and therapeutic advances.Signal transduction and targeted therapy · 2026
    Review
  5. Article
  6. Review
  7. Cancer-Associated Cachexia in the Era of Obesity.International journal of molecular sciences · 2025
    Review
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  9. Article
  10. Review
  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Alessio MolfinoDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.ORCID 0000-0002-6432-0236
Raffaella CarlettiDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Giovanni ImbimboDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Maria Ida AmabileDepartment of Surgical Sciences, Sapienza University of Rome, Rome, Italy.
Roberta BelliDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Cira R T di GioiaDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy.
Elena BelloniDepartment of Medical-Surgical Sciences and Translational Medicine, Sapienza University of Rome, Rome, Italy.
Francesco SpinelliDepartment of Medical-Surgical Sciences and Translational Medicine, Sapienza University of Rome, Rome, Italy.
Veronica RizzoDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy.
Carlo CatalanoDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy.
Giuseppe NigriDepartment of Medical-Surgical Sciences and Translational Medicine, Sapienza University of Rome, Rome, Italy.
Maurizio MuscaritoliDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDuring cancer cachexia, several alterations occur in peripheral tissues, and the adipose tissue may be involved during the catabolic state. We aimed at investigating histological rearrangement and infiltration of inflammatory cells in subcutaneous adipose tissue (SAT) of patients with cancer undergoing surgery, according to the presence/absence of cachexia.

methodsWe considered gastrointestinal cancer patients and controls with non-malignant diseases undergoing surgery. We collected SAT samples and performed histomorphological analyses [cross-sectional area (CSA) and per cent of fibrosis] and immunohistochemistry to characterize the inflammatory cells. By computed tomography (CT) scan, we calculated SAT and visceral adipose tissue (VAT).

resultsWe enrolled 51 participants (31 gastrointestinal cancer patients and 20 controls). In cancer patients, cachexia was present in 13/31 (42%). The CSA (μm

conclusionsWe found histological alterations of SAT among gastrointestinal cancer patients and in particular significant changes in CSA, fibrosis, and inflammation when cachexia was present; the changes in histomorphological parameters of the adipocytes reflected alterations in adiposity at body composition analysis.

Indexed as

CachexiaGastrointestinal NeoplasmsAdipose TissueHumansIntra-Abdominal FatSubcutaneous FatAdipose tissueBody compositionCachexiaCancerFibrosisInflammation

Identifiers

PMID34939367
PMCPMC8818610
OpenAlexW4200157498

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.