Evidence map›Paper›PMID 34939359›Full record

ArticleESC heart failure2022

Impact of intraventricular haemodynamic forces misalignment on left ventricular remodelling after myocardial infarction.

Domenico Filomena, Sara Cimino, Sara Monosilio, Nicola Galea, Giuseppe Mancuso, Marco Francone, Giovanni Tonti, Gianni Pedrizzetti, Viviana Maestrini, Francesco Fedele and 1 more

Abstract read
In one paragraph

Article in ESC heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
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  7. Hypertrabeculation in Olympic Athletes: Advanced LV Function Analysis by CMR.Journal of cardiovascular development and disease · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Assessing cardiac mechanics through left ventricular haemodynamic forces.European heart journal. Imaging methods and practice · 2024
    Review
  12. Article
  13. Article
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Domenico FilomenaDepartment of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, 'Sapienza' University of Rome, Policlinico Umberto I, Viale del Policlinico 155, Rome, 00161, Italy.ORCID 0000-0002-1515-506X
Sara CiminoDepartment of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, 'Sapienza' University of Rome, Policlinico Umberto I, Viale del Policlinico 155, Rome, 00161, Italy.
Sara MonosilioDepartment of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, 'Sapienza' University of Rome, Policlinico Umberto I, Viale del Policlinico 155, Rome, 00161, Italy.
Nicola GaleaDepartment of Radiological, Oncological, and Pathological Sciences, 'Sapienza' University of Rome, Rome, Italy.
Giuseppe MancusoDepartment of Radiological, Oncological, and Pathological Sciences, 'Sapienza' University of Rome, Rome, Italy.
Marco FranconeDepartment of Radiological, Oncological, and Pathological Sciences, 'Sapienza' University of Rome, Rome, Italy.
Giovanni TontiCardiology Division, 'G. D'Annunzio' University, Chieti, Italy.
Gianni PedrizzettiDepartment of Engineering and Architecture, University of Trieste, Trieste, Italy.
Viviana MaestriniDepartment of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, 'Sapienza' University of Rome, Policlinico Umberto I, Viale del Policlinico 155, Rome, 00161, Italy.
Francesco FedeleDepartment of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, 'Sapienza' University of Rome, Policlinico Umberto I, Viale del Policlinico 155, Rome, 00161, Italy.
Luciano AgatiDepartment of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, 'Sapienza' University of Rome, Policlinico Umberto I, Viale del Policlinico 155, Rome, 00161, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsAltered left ventricular (LV) haemodynamic forces (HDFs) have been associated with positive and negative remodelling after pathogenic or therapeutic events. We aimed to identify LV HDFs patterns associated with adverse LV remodelling (aLVr) in reperfused segment elevation myocardial infarction (STEMI) patients. METHODS AND

resultsForty-nine acute STEMI patients underwent cardiac magnetic resonance (CMR) at 1 week (baseline) and after 4 months (follow-up). LV HDFs were computed at baseline from cine CMR long axis data sets, using a novel technique based on endocardial boundary tracking, both in apex-base (A-B) and latero-septal (L-S) directions. HDFs distribution was evaluated by L-S over A-B HDFs ratio (L-S/A-B HDFs ratio %). HDFs parameters were computed over the entire heartbeat, in systole and diastole. At baseline, aLVr patients had lower systolic L-S HDF (2.7 ± 0.9 vs. 3.6 ± 1%; P = 0.027) and higher diastolic L-S/A-B HDF ratio (28 ± 14 vs. 19 ± 6%; P = 0.03). At univariate logistic regression analysis, higher infarct size [odds ratio (OR) 1.05; 95% confidence interval (CI) 1.01-1.1; P = 0.04], higher L-S/A-B HDFs ratio (OR 1.1; 95% CI 1.01-1.2; P = 0.05) and lower L-S HDFs (OR 0.41; 95% CI 0.2-0.9; P = 0.04) were associated with aLVr at follow-up. In the multivariable logistic regression analysis, diastolic L-S/A-B HDF ratio remained the only independent predictor of aLVr (OR 1.1; 95% CI 1.01-1.2; P = 0.04).

conclusionsMisalignment of diastolic haemodynamic forces after STEMI is associated with aLVr after 4 months.

Indexed as

Myocardial InfarctionST Elevation Myocardial InfarctionHemodynamicsHumansMagnetic Resonance Imaging, CinePredictive Value of TestsVentricular Function, LeftVentricular RemodelingAdverse remodellingCMRHaemodynamic forcesSTEMI

Identifiers

PMID34939359
PMCPMC8787983

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.