Evidence map›Paper›PMID 34939322›Full record

ReviewPediatric blood & cancer2022

Therapy-related myeloid neoplasms resembling juvenile myelomonocytic leukemia: a case series and review of the literature.

Astrid Wintering, Stephen Smith, Beng Fuh, Arun Rangaswami, Gary Dahl, May Chien, Tanja A Gruber, Jinjun Dang, Loretta S Li, Alicia Lenzen and 4 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pediatric blood & cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Genotoxicity of cancer therapies and the risk of secondary malignancies: toward personalized prevention.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Astrid WinteringDepartment of Pediatrics, UCSF Benioff Children's Hospital San Francisco, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0002-3731-6928
Stephen SmithDepartment of Pediatrics, UCSF Benioff Children's Hospital Oakland, Oakland, California, USA.
Beng FuhDepartment of Pediatrics, East Carolina University, Greenville, North Carolina, USA.
Arun RangaswamiDepartment of Pediatrics, UCSF Benioff Children's Hospital San Francisco, University of California San Francisco, San Francisco, California, USA.
Gary DahlDepartment of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
May ChienDepartment of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
Tanja A GruberDepartment of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
Jinjun DangDepartment of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
Loretta S LiDepartment of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
Alicia LenzenDepartment of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
Stephanie SavelliDepartment of Pediatrics, Akron Children's Hospital, Akron, Ohio, USA.
Christopher C DvorakDepartment of Pediatrics, UCSF Benioff Children's Hospital San Francisco, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0002-6146-3952
Anurag K AgrawalDepartment of Pediatrics, UCSF Benioff Children's Hospital Oakland, Oakland, California, USA.ORCID 0000-0003-4898-9615
Elliot StieglitzDepartment of Pediatrics, UCSF Benioff Children's Hospital San Francisco, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0001-7032-4623
University of California, San Francisco · USStanford University · USLurie Children's Hospital · USAkron Children's Hospital · USEast Carolina University · USUCSF Benioff Children's Hospital · US

Funding

Targeting SETBP1 in Myeloproliferative DisordersK08HL135434 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STIEGLITZ, ELLIOT · 2017 to 2021
$900k
NHLBI NIH HHS K08 HL135434
6 · The paper itself

Abstract

Therapy-related myeloid neoplasms (t-MN) are a distinct subgroup of myeloid malignancies with a poor prognosis that include cases of therapy-related myelodysplastic syndrome (t-MDS), therapy-related myeloproliferative neoplasms (t-MPN) and therapy-related acute myeloid leukemia (t-AML). Here, we report a series of patients with clinical features consistent with juvenile myelomonocytic leukemia (JMML), an overlap syndrome of MDS and myeloproliferative neoplasms that developed after treatment for another malignancy.

Indexed as

Leukemia, Myelomonocytic, JuvenileMyelodysplastic SyndromesMyeloproliferative DisordersNeoplasms, Second PrimaryHumansAMLJMMLMDSsecondarytherapy related

Identifiers

PMID34939322
PMCPMC8957526
OpenAlexW4200118702

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.