ArticleJournal of veterinary internal medicine2022
Effect of washing units of canine red blood cells on storage lesions.
Article in Journal of veterinary internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 2 citations in OpenAlex.
- Donor- and unit-specific factors influencing hemolysis in stored canine and feline packed red blood cells.Frontiers in veterinary science · 2026Article
- Efficacy of different storage methods and duration of blood samples on biochemical indexes in healthy blood donors.Pakistan journal of medical sciences · 2025Article
- Effect of washing units of canine red blood cells on storage lesions.Journal of veterinary internal medicine · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn humans, washing stored blood products before transfusion reduces storage lesions and incidence of transfusion reactions, but the effectiveness of washing canine blood is unknown.
objectivesThe objective was to determine if manually washing units of stored blood would reduce storage lesions without adversely affecting erythrocytes. We hypothesized that washing stored units would reduce concentrations of storage lesions and cause minimal erythrocyte damage. ANIMALS: Eight healthy research dogs.
methodsRepeated measure cohort study. Units of whole blood were stored for 28 days and washed 3 times with 0.9% NaCl. Blood samples were collected before and after storage, after each wash, and after being held at a simulated transfusion temperature. Variables measured included CBC variables, blood gas analysis, erythrocyte morphology, mean corpuscular fragility (MCF), and eicosanoid concentrations. A Friedman's test was used to evaluate changes in variables (P < .05 was considered significant).
resultsAfter the first wash, compared to values after storage, there was a significant decrease in potassium (4.3 mmol/L [4.0-4.7] to 1.2 mmol/L [1-1.6]; P < .0001, median [range]), lactate (1.45 mmol/L [1.07-1.79] to 0.69 mmol/L [0.39-0.93]; P = .002), and partial pressure carbon dioxide (102 mm Hg [80.2-119.2] to 33.7 mm Hg [24.5-44.5]; P < .0001), and increase in MCV (69.3 fL [65.7-72.3] to 74 fL [69.6-79.5]; P = .0003), and MCF (0.444 fL [0.279-0.527] to 0.491 fL [0.43-0.616]; P = .0006). CONCLUSIONS AND CLINICAL IMPORTANCE: A single wash of stored whole blood significantly reduces most extracellular storage lesions, and additional washing might cause hemolysis.
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