Evidence map›Paper›PMID 34939228›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2022

Addressing the Challenges of Clinical Research for Freezing of Gait in Parkinson's Disease.

Simon J G Lewis, Stewart A Factor, Nir Giladi, Mark Hallett, Alice Nieuwboer, John G Nutt, Serge Przedborski, Stella M Papa, MDS Scientific Issues Committee

Abstract read
In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. What is new in Freezing of Gait?Journal of neurology · 2026
    Review
  4. An updated definition of freezing of gait.Nature reviews. Neurology · 2026
    Review
  5. Article
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  7. Review
  8. Article
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  15. Article
  16. Review
  17. Discussion of Research Priorities for Gait Disorders in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Simon J G LewisForeFront Parkinson's Disease Research Clinic, Brain and Mind Centre, School of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia.
Stewart A FactorJean and Paul Amos Parkinson's Disease and Movement Disorders Program, Emory University School of Medicine, Atlanta, Georgia, USA.
Nir GiladiMovement Disorders Unit, Department of Neurology, Tel-Aviv Sourasky Medical Center, Sackler School of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
Mark HallettHuman Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0002-3180-6811
Alice NieuwboerDepartment of Rehabilitation Sciences, KU Leuven, Leuven, Belgium.ORCID 0000-0003-1193-6229
John G NuttMovement Disorder Section, Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA.ORCID 0000-0003-2759-1106
Serge PrzedborskiDepartments of Pathology & Cell Biology, Neurology, and Neuroscience, Columbia University, New York, New York, USA.
Stella M PapaDepartment of Neurology, School of Medicine, and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.ORCID 0000-0003-3010-6343
MDS Scientific Issues Committee

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Pathophysiology of Basal Ganglia DisordersZIANS003031 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI HALLETT, MARK · 2009 to 2023
$22.7M
Regulation of Motor Function in Parkinson's DiseaseR01NS045962 · NINDS · EMORY UNIVERSITY · PI PAPA, STELLA M, TRAYNELIS, STEPHEN F · 2004 to 2022
$5.2M
Manipulating Gene Expression in the Dyskinesias of Parkinson's DiseaseR01NS073994 · NINDS · EMORY UNIVERSITY · PI MOURADIAN, M. MARAL, PAPA, STELLA M · 2011 to 2016
$2.4M
Regulation of Motor Function in Parkinson's DiseaseR56NS045962 · NINDS · EMORY UNIVERSITY · PI PAPA, STELLA M, TRAYNELIS, STEPHEN F · 2018 to 2018
$603k
Dopamine signal transduction in striatal neurons in Parkinson’s diseaseR21NS125502 · NINDS · EMORY UNIVERSITY · PI PAPA, STELLA M · 2021 to 2021
$501k
A novel gene therapy for motor symptoms of Parkinson's diseaseR21NS110416 · NINDS · EMORY UNIVERSITY · PI PAPA, STELLA M · 2019 to 2019
$483k
NIH HHS P51 OD011132NINDS NIH HHS R01 NS045962NINDS NIH HHS R01 NS073994NINDS NIH HHS R21 NS110416NINDS NIH HHS R21 NS125502NINDS NIH HHS R56 NS045962
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gait Disorders, NeurologicParkinson DiseaseGaitHumans

Identifiers

PMID34939228
PMCPMC8840955

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.