Evidence map›Paper›PMID 34939221›Full record

ReviewMovement disorders : official journal of the Movement Disorder Society2022

Discussion of Research Priorities for Gait Disorders in Parkinson's Disease.

Nicolaas I Bohnen, Rui M Costa, William T Dauer, Stewart A Factor, Nir Giladi, Mark Hallett, Simon J G Lewis, Alice Nieuwboer, John G Nutt, Kaoru Takakusaki and 4 more

Open access · greenAbstract readReview
In one paragraph

Review in Movement disorders : official journal of the Movement Disorder Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. An updated definition of freezing of gait.Nature reviews. Neurology · 2026
    Review
  4. Article
  5. Review
  6. Does the Severity of Arm Tremor in Essential Tremor Correlate with Impaired Balance?Tremor and other hyperkinetic movements (New York, N.Y.) · 2026
    Article
  7. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 5 countries.

Nicolaas I BohnenDepartments of Radiology and Neurology, University of Michigan and VA Ann Arbor Healthcare System, Ann Arbor, Michigan, USA.ORCID 0000-0003-0352-6414
Rui M CostaDepartments of Neuroscience and Neurology, Zuckerman Mind Brain Behavior Institute, Columbia University, New York, New York, USA.
William T DauerDepartments of Neurology and Neuroscience, The Peter O'Donnell Jr. Brain Institute, UT Southwestern, Dallas, Texas, USA.
Stewart A FactorJean and Paul Amos Parkinson's Disease and Movement Disorders Program, Emory University School of Medicine, Atlanta, Georgia, USA.
Nir GiladiMovement Disorders Unit, Department of Neurology, Tel-Aviv Sourasky Medical Center, Sackler School of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
Mark HallettHuman Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0002-3180-6811
Simon J G LewisForeFront Parkinson's Disease Research Clinic, Brain and Mind Centre, School of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia.
Alice NieuwboerDepartment of Rehabilitation Sciences, KU Leuven, Leuven, Belgium.ORCID 0000-0003-1193-6229
John G NuttMovement Disorder Section, Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA.ORCID 0000-0003-2759-1106
Kaoru TakakusakiDepartment of Physiology, Section of Neuroscience, Asahikawa Medical University, Asahikawa, Japan.
Un Jung KangDepartments of Neurology, Neuroscience, and Physiology, Neuroscience Institute, The Marlene and Paolo Fresco Institute for Parkinson's and Movement Disorders, The Parekh Center for Interdisciplinary Neurology, New York University Grossman School of Medicine, New York, New York, USA.ORCID 0000-0002-5970-6839
Serge PrzedborskiDepartments of Pathology and Cell Biology, Neurology, and Neuroscience, Columbia University, New York, New York, USA.
Stella M PapaDepartment of Neurology, School of Medicine, and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
MDS-Scientific Issues Committee
Columbia University · USEmory University · USAsahikawa Medical University · JPKU Leuven · BENational Institutes of Health · USNew York University · USOregon Health & Science University · USTel Aviv University · ILThe University of Sydney · AUThe University of Texas Southwestern Medical Center · USUniversity of Michigan · US

Funding

Pathophysiology of Basal Ganglia DisordersZIANS003031 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI HALLETT, MARK · 2009 to 2023
$22.7M
Udall Catalyst Research Project: Retrosplenial Cholinergic and Attentional-Motor Integration DysfunctionP50NS123067 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AHMED, OMAR JAMIL · 2021 to 2025
$11.6M
Public Outreach and Education CoreP50NS091856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOHNEN, NICOLAAS IDA · 2014 to 2019
$10.1M
Regulation of Motor Function in Parkinson's DiseaseR01NS045962 · NINDS · EMORY UNIVERSITY · PI PAPA, STELLA M, TRAYNELIS, STEPHEN F · 2004 to 2022
$5.2M
Central cholinergic presbyvestibulopathy network changes and imbalance in Parkinson's disease and older personsR01AG073100 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOHNEN, NICOLAAS IDA · 2021 to 2025
$3.0M
Gene therapy targeting striatal dysfunction for Parkinson’s diseaseR01NS126924 · NINDS · EMORY UNIVERSITY · PI Stella M Papa · 2022 to 2026
$2.7M
Modulation of GABA-A Receptors and Axial Motor Impairments in Parkinson DiseaseR01NS099535 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOHNEN, NICOLAAS IDA · 2017 to 2020
$2.1M
A transcriptomic atlas of immune cells in a model of synucleinopathyR21AG064596 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PRZEDBORSKI, SERGE E · 2019 to 2020
$446k
Focused ultrasound and synucleinopathyR21NS111176 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PRZEDBORSKI, SERGE E · 2019 to 2019
$446k
Amyloidopathy, cholinopathy, dopamine responsiveness and freezing of gait in PDI01RX001631 · VA · VETERANS HEALTH ADMINISTRATION · PI BOHNEN, NICOLAAS IDA · 2016 to 2020
–
IMAGING BIOMARKERS OF PROGRESSION OF MOBILITY IMPAIRMENT IN PDI01RX000317 · VA · VETERANS HEALTH ADMINISTRATION · PI BOHNEN, NICOLAAS IDA · 2012 to 2014
–
Vestibulopathy, imbalance and gait disturbances in Parkinson diseaseI01RX003397 · VA · VETERANS HEALTH ADMINISTRATION · PI Nicolaas Ida Bohnen · 2021 to 2026
–
NIA NIH HHS R01 AG073100NIA NIH HHS R21 AG064596NINDS NIH HHS P50 NS091856NINDS NIH HHS P50 NS123067NINDS NIH HHS R01 NS045962NINDS NIH HHS R01 NS099535NINDS NIH HHS R01 NS126924NINDS NIH HHS R21 NS111176RRD VA I01 RX000317RRD VA I01 RX001631RRD VA I01 RX003397
6 · The paper itself

Abstract

Gait and balance abnormalities develop commonly in Parkinson's disease and are among the motor symptoms most disabling and refractory to dopaminergic or other treatments, including deep brain stimulation. Efforts to develop effective therapies are challenged by limited understanding of these complex disorders. There is a major need for novel and appropriately targeted research to expedite progress in this area. The Scientific Issues Committee of the International Parkinson and Movement Disorder Society has charged a panel of experts in the field to consider the current knowledge gaps and determine the research routes with highest potential to generate groundbreaking data. © 2021 International Parkinson and Movement Disorder Society.

Indexed as

Gait Disorders, NeurologicParkinson DiseaseDopamineGaitHumansResearchDopaminebalanceFOGfreezinggaitParkinson's diseaseresearch priorities

Identifiers

PMID34939221
PMCPMC10122497
OpenAlexW4200073935

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.