Evidence map›Paper›PMID 34939198›Full record

ArticleFEBS letters2022

Polyoxovanadates as new P-glycoprotein inhibitors: insights into the mechanism of inhibition.

Diogo Henrique Kita, Gisele Alves de Andrade, Juliana Morais Missina, Kahoana Postal, Viktor Kalbermatter Boell, Francielli Sousa Santana, Ingrid Fatima Zattoni, Isadora da Silva Zanzarini, Vivian Rotuno Moure, Fabiane Gomes de Moraes Rego and 6 more

Abstract read
In one paragraph

Article in FEBS letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Diogo Henrique KitaPharmaceutical Sciences Graduate Program, Laboratory of Cancer Drug Resistance, Federal University of Paraná, Curitiba, Brazil.
Gisele Alves de AndradePharmaceutical Sciences Graduate Program, Laboratory of Cancer Drug Resistance, Federal University of Paraná, Curitiba, Brazil.
Juliana Morais MissinaDepartment of Chemistry, Federal University of Paraná, Curitiba, Brazil.
Kahoana PostalDepartment of Chemistry, Federal University of Paraná, Curitiba, Brazil.
Viktor Kalbermatter BoellDepartment of Chemistry, Federal University of Paraná, Curitiba, Brazil.
Francielli Sousa SantanaDepartment of Chemistry, Federal University of Paraná, Curitiba, Brazil.
Ingrid Fatima ZattoniPharmaceutical Sciences Graduate Program, Laboratory of Cancer Drug Resistance, Federal University of Paraná, Curitiba, Brazil.
Isadora da Silva ZanzariniPharmaceutical Sciences Graduate Program, Laboratory of Cancer Drug Resistance, Federal University of Paraná, Curitiba, Brazil.
Vivian Rotuno MourePharmaceutical Sciences Graduate Program, Laboratory of Cancer Drug Resistance, Federal University of Paraná, Curitiba, Brazil.
Fabiane Gomes de Moraes RegoDepartment of Clinical Analysis, Federal University of Paraná, Curitiba, Brazil.
Geraldo PichethDepartment of Clinical Analysis, Federal University of Paraná, Curitiba, Brazil.
Emanuel Maltempi de SouzaDepartment of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, Brazil.
David A MitchellDepartment of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, Brazil.ORCID 0000-0001-9355-5520
Suresh V AmbudkarLaboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-2639-4955
Giovana Gioppo NunesDepartment of Chemistry, Federal University of Paraná, Curitiba, Brazil.
Glaucio ValdameriPharmaceutical Sciences Graduate Program, Laboratory of Cancer Drug Resistance, Federal University of Paraná, Curitiba, Brazil.ORCID 0000-0003-1882-1512

Funding

Biochemical Analysis of Multidrug Resistance-linked Transport ProteinsZIABC010030 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI AMBUDKAR, SURESH · 2009 to 2025
$21.6M
Multidrug Resistance-linked Transport ProteinsZ01BC010030 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI AMBUDKAR, SURESH · 1996 to 2008
$2.3M
Intramural NIH HHS Z01 BC010030
6 · The paper itself

Abstract

A promising strategy to overcome multidrug resistance is the use of inhibitors of ABC drug transporters. For this reason, we evaluated the polyoxovanadates (POVs) [V

Indexed as

ATP-Binding Cassette, Sub-Family C ProteinsATP Binding Cassette Transporter, Subfamily G, Member 2AnimalsATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1Drug Resistance, MultipleHumansNeoplasm ProteinsTungsten CompoundsABCG2 protein, humanATP-Binding Cassette, Sub-Family C ProteinsATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1ATP Binding Cassette Transporter, Subfamily G, Member 2multidrug resistance-associated protein 1Neoplasm ProteinsTungsten CompoundsABC transporterscancerinhibitorsmultidrug resistanceP-glycoproteinpolyoxovanadates

Identifiers

PMID34939198
PMCPMC9340886

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.