Evidence map›Paper›PMID 34939143›Full record

ArticleEuropean child & adolescent psychiatry2023

The absence of association between anorexia nervosa and smoking: converging evidence across two studies.

E Caitlin Lloyd, Zoe E Reed, Robyn E Wootton

Open access · hybridAbstract read
In one paragraph

Article in European child & adolescent psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Utilising genomic association data for causal inference in anorexia nervosa.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Review
  2. Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 3 countries.

E Caitlin LloydDepartment of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA. caitlin.lloyd@nyspi.columbia.edu.ORCID http://orcid.org/0000-0003-4044-9550
Zoe E ReedSchool of Psychological Science, University of Bristol, Priory Road, Bristol, UK.
Robyn E WoottonMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
University of Bristol · GBColumbia University Irving Medical Center · US

Funding

Research Training in Biobehavioral Disturbances of Eating DisordersT32MH096679 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EVELYN ATTIA, B. TIMOTHY WALSH · 2013 to 2026
$2.4M
Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MC_UU_00011/7NIMH NIH HHS T32 MH096679Wellcome Trust
6 · The paper itself

Abstract

Previous studies have found increased smoking prevalence amongst adults with anorexia nervosa (AN) compared to the general population. The current investigation explored bidirectional associations between AN and smoking behaviour (initiation and heaviness), to address questions surrounding causation. In Study One, logistic regression models with variance robust standard errors assessed longitudinal associations between AN and smoking, using data from adolescent participants of the Avon Longitudinal Study of Parents and Children (N = 5100). In Study Two, two-sample Mendelian randomisation (MR) tested possible causal effects using summary statistics from publicly available genome-wide association studies (GWAS). Study One provided no clear evidence for a predictive effect of AN on subsequent smoking behaviour, or for smoking heaviness/initiation predicting later AN. MR findings did not support causal effects between AN and smoking behaviour, in either direction. Findings do not support predictive or causal effects between AN and smoking behaviour. Previously reported associations may have been vulnerable to confounding, highlighting the possibility of smoking and AN sharing causal risk factors.

Indexed as

Anorexia NervosaGenome-Wide Association StudyAdolescentAdultChildHumansLongitudinal StudiesPolymorphism, Single NucleotideRisk FactorsSmokingAnorexia nervosaEpidemiologyLongitudinalMendelian randomizationSmokingTriangulation

Identifiers

PMID34939143
PMCPMC10276073
OpenAlexW4200262806

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.