ArticleACS measurement science au2021
Bipolar Electrochemical Measurement of Enantiomeric Excess with Inherently Chiral Polymer Actuators.
Article in ACS measurement science au, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Chiral Twin-Electrodes for Amplifying the Faradaic Current of Enantiomers via Redox Cycling.ACS measurement science au · 2026Article
- Experimental Methods for Measuring Potential and Current Density Distributions at Bipolar Electrodes.Analytical chemistry · 2025Article
- Unconventional approaches for chiral resolution.Analytical and bioanalytical chemistry · 2024Review
- Bi-enzymatic chemo-mechanical feedback loop for continuous self-sustained actuation of conducting polymers.Nature communications · 2023Article
- Wireless electrochemical actuation of soft materials towards chiral stimuli.Chemical communications (Cambridge, England) · 2023Review
- BINOL-Containing Chiral Porous Polymers as Platforms for Enantiorecognition.ACS applied materials & interfaces · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Straightforward enantioselective analytical methods are very important for drug safety, considering that in certain cases one of the two enantiomers of a chiral molecule might be harmful for humans. In this work, we propose a simple system for the direct and easy read-out of the enantiomeric excess of 3,4-dihydroxyphenylalanine (DOPA) as a model analyte. A conducting oligomer, i.e. oligo-(3,3'-dibenzothiophene), bearing inherently chiral features, is electrogenerated on a polypyrrole film. The resulting freestanding hybrid material is used as a wireless enantioselective actuator in a bipolar electrochemical cell. Combining in a single setup two individual actuators with opposite chiral features allows a direct visual read-out of enantiomeric excess, as the bending amplitude of each of the two actuators is directly correlated with the concentration of the corresponding stereoisomer of the analyte. Optimization of the experimental parameters results in efficient bending, giving access to the percentage values of the enantiomeric excess in mixtures containing different ratios of the antipodes, thus opening the way to potential applications for chiral in situ analysis.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.