Evidence map›Paper›PMID 34939034›Full record

ArticleCritical care explorations2021

Epidemiology and Outcome of Sepsis in Adults and Children in a Rural, Sub-Sahara African Setting.

Arthur Kwizera, Olivier Urayeneza, Pierre Mujyarugamba, Inipavudu Baelani, Jens Meier, Mervyn Mer, Ndidiamaka Musa, Niranjan Kissoon, Andrew J Patterson, Joseph C Farmer and 1 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care explorations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07079605 (Cardiac Manifestations of Sepsis and Its Association With Disease Outcome), which is not on this map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07079605 recruitingnot on this mapstarted 2025, after this paper: background citation

Cardiac Manifestations of Sepsis and Its Association With Disease Outcome: A Prospective Cohort Study

Typeobservational_patient_registrySponsorJimma UniversityRan2025 to 2026Enrolled226ConditionsSepsis-related MyocarditisArmsStandard treatment for sepsis of any focus, Treatment for the sepsis with standard management of cardiac failure
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 7 countries.

Arthur KwizeraDepartment of Anaesthesia and Critical Care, Makerere University College of Health Sciences, Kampala, Uganda.
Olivier UrayenezaGitwe Hospital and Gitwe School of Medicine, Gitwe, Rwanda.
Pierre MujyarugambaGitwe Hospital and Gitwe School of Medicine, Gitwe, Rwanda.
Inipavudu BaelaniGreat Lakes Free University, Goma, Democratic Republic of Congo.
Jens MeierDepartment of Anesthesiology and Intensive Care Medicine, Kepler University Hospital and Johannes Kepler University Linz, Linz, Austria.
Mervyn MerDepartment of Medicine, Divisions of Critical Care and Pulmonology, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Ndidiamaka MusaSeattle Children's Hospital, University of Washington, Seattle, WA.
Niranjan KissoonBC Children's Hospital, University of British Columbia, Vancouver, BC, Canada.
Andrew J PattersonDepartment of Anesthesiology, Emory University, Atlanta, GA.
Joseph C FarmerDepartment of Critical Care Medicine, Mayo Clinic, Phoenix, AZ.
Martin W DünserDepartment of Anesthesiology and Intensive Care Medicine, Kepler University Hospital and Johannes Kepler University Linz, Linz, Austria.
Institut Supérieur Pédagogique de Gitwe · RWJohannes Kepler University of Linz · ATEmory University · USJohannesburg Hospital · ZAMakerere University · UGMayo Clinic Hospital · USSeattle Children's Hospital · USUniversity of British Columbia · CAUniversity of Goma · CD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo identify the epidemiology and outcome of adults and children with and without sepsis in a rural sub-Sahara African setting.

designA priori planned substudy of a prospective, before-and-after trial.

settingRural, sub-Sahara African hospital. PATIENTS: One-thousand four-hundred twelve patients (adults,

interventionsNone. MEASUREMENTS AND MAIN

resultsDemographic, clinical, laboratory data, danger signs, and the presence of sepsis (defined as a quick Sequential Organ Failure Assessment score count ≥ 2) at admission were extracted. Sepsis was observed in 69 adults (14.1%) and 248 children (26.9%). Sepsis patients differed from subjects without sepsis in several demographic and clinical aspects. Malaria was the most frequent type of infection in adults (66.7%) and children (63.7%) with sepsis, followed by suspected bacterial and parasitic infections other than malaria. Adults with sepsis more frequently developed respiratory failure (8.7% vs 2.1%;

conclusionsIn addition to suspected bacterial, viral, and fungal infections, malaria and other parasitic infections are common and important causes of sepsis in adults and children admitted to a rural hospital in sub-Sahara Africa. The in-hospital mortality associated with sepsis is substantial, primarily in adults.

Indexed as

AfricaepidemiologymalariaoutcomeRwandasepsis

Identifiers

PMID34939034
PMCPMC8687731
OpenAlexW4200041074

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.