ArticleKidney medicine
Health-Related Quality of Life in Older Kidney Transplant Recipients: A National Cohort Study of Short- and Longer-Term Outcomes.
Article in Kidney medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Patient-reported Outcome Measures in Solid Organ Transplant Recipients: Current use, Challenges, and Recommendations for Future use.Transplantation · 2026Review
- Pain Interference in Maintenance Hemodialysis: A Single-Center Cross-Sectional Study Using the Pain Effects Scale (PES).Journal of clinical medicine · 2026Article
- Effect of Tai Chi Exercise on Fatigue in Renal Transplant Recipients: A Randomized Controlled Trial.Nursing research and practice · 2026Article
- Health-related quality of life in kidney transplant recipients: association with graft function and comparison to patients on dialysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Frailty Matters-But Contextualize the Clinical Decision.Kidney international reports · 2025Article
- Frailty Impact on Kidney Transplantation in Older People.Kidney international reports · 2025Article
- Insights Into Health-Related Quality of Life of Kidney Transplant Recipients: A Narrative Review of Associated Factors.Kidney medicine · 2025Review
- COVID-19 and Access to Kidney Transplantation for Older Candidates in the United States: A National Registry Study.Kidney medicine · 2024Article
- Kidney Transplantation Improves Health-Related Quality of Life in Older Recipients.Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
- Evolving Trends in Kidney Transplant Outcomes Among Older Adults: A Comparative Analysis Before and During the COVID-19 Pandemic.Transplantation direct · 2023Article
- Patient Preferences for the Management of Gastrointestinal Symptoms in Kidney Transplantation: a Discrete Choice Experiment.Kidney international reports · 2023Article
- A Comorbidity Index and Pretransplant Physical Status Predict Survival in Older Kidney Transplant Recipients: A National Prospective Study.Transplantation direct · 2022Article
- Adult Living-Donor Kidney Transplantation, Donor Age, and Donor-Recipient Age.Kidney international reports · 2021Article
- The impact of chronic kidney disease on health-related quality of life (HRQoL): key insights from a hospital-based cross-sectional study.Jornal brasileiro de nefrologiaArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RATIONALE &
objectiveAssessing the optimal therapy for older patients (aged ≥65 years) with end-stage kidney disease requires knowledge of longevity and health-related quality of life (HRQoL) outcomes. Kidney transplantation prolongs survival but its long-term impact on HRQoL in older recipients is not well defined. We aimed to prospectively evaluate HRQoL changes from enlisting until 3 years posttransplantation and examine pretransplantation predictors of posttransplantation outcomes. STUDY
designProspective cohort study. SETTING &
participantsPatients 65 years and older enlisted at the Norwegian National Transplant Center between January 2013 and November 2016. PREDICTORS: Kidney transplantation, dialysis vintage, and pretransplantation comorbidity assessed using the Liu Comorbidity Index. OUTCOMES: HRQoL, assessed using the Kidney Disease Quality of Life Short Form, version 1.3. ANALYTICAL APPROACH: HRQoL scores obtained at 3 years posttransplantation were compared with those obtained pretransplantation and after 1 year using a paired-sample
resultsAmong 289 patients included, 220 (mean age, 71.5 years) had undergone transplantation and 136 had completed the 3-year HRQoL follow-up by October 2020. Posttransplant HRQoL, both generic and kidney specific, substantially improved and the benefit persisted for 3 years. For wait-listed candidates remaining on dialysis, HRQoL gradually deteriorated, and recipients who died within 3 years posttransplantation experienced no improvement during the first year. Moderately elevated pretransplantation comorbidity scores and prolonged dialysis vintage independently predicted poor HRQoL outcomes posttransplantation. Recipients receiving dialysis for 1 year or longer with pretransplantation comorbidity scores ≥ 7 experienced a marked and sustained physical deterioration after transplantation. LIMITATIONS: Homogenous and highly selected population.
conclusionsTransplantation is associated with a sustained HRQoL improvement and should be the preferred treatment for selected older patients. The value of a pretransplant comorbidity score to predict posttransplantation outcomes warrants further evaluation and may improve the selection process.
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