Evidence map›Paper›PMID 34939001›Full record

ArticleKidney medicine

Kidney Recovery in Patients With Acute Kidney Injury Treated in Outpatient Hemodialysis or Rehabilitation Facilities.

Melissa Jordan, Victor Ortiz-Soriano, Aaron Pruitt, Lauren Chism, Lucas J Liu, Nourhan Chaaban, Madona Elias, B Peter Sawaya, Jin Chen, Javier A Neyra

Open access · goldAbstract read
In one paragraph

Article in Kidney medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Melissa JordanDepartment of Internal Medicine, University of Kentucky, Lexington, KY.
Victor Ortiz-SorianoDivision of Nephrology, Bone and Mineral Metabolism, University of Kentucky, Lexington, KY.
Aaron PruittDivision of Nephrology, Bone and Mineral Metabolism, University of Kentucky, Lexington, KY.
Lauren ChismDivision of Nephrology, Bone and Mineral Metabolism, University of Kentucky, Lexington, KY.
Lucas J LiuDepartment of Computer Science, University of Kentucky, Lexington, KY.
Nourhan ChaabanDivision of Nephrology, Bone and Mineral Metabolism, University of Kentucky, Lexington, KY.
Madona EliasDivision of Nephrology, Bone and Mineral Metabolism, University of Kentucky, Lexington, KY.
B Peter SawayaDivision of Nephrology, Bone and Mineral Metabolism, University of Kentucky, Lexington, KY.
Jin ChenDepartment of Internal Medicine, University of Kentucky, Lexington, KY.
Javier A NeyraDivision of Nephrology, Bone and Mineral Metabolism, University of Kentucky, Lexington, KY.
University of Kentucky · US

Funding

UAB-UCSD O'Brien Core Center for Acute Kidney Injury ResearchP30DK079337 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGARWAL, ANUPAM · 2008 to 2022
$18.3M
Blood and Urine Biomarkers for Predicting Long-Term Adverse Kidney and Cardiovascular Outcomes after Cardiac SurgeryR01HL148448 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI FOX, AMANDA A · 2019 to 2023
$3.7M
Association of baseline and time-varying serum magnesium levels with cardiovascular disease events in SPRINT participants with and without chronic kidney diseaseR21HL145424 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2019 to 2020
$257k
Artificial Intelligence to Predict Outcomes in Patients with Acute Kidney Injury on Continuous Renal Replacement TherapyR56DK126930 · NIDDK · UNIVERSITY OF KENTUCKY · PI NADKARNI, GIRISH NITIN, NEYRA, JAVIER A. · 2020 to 2020
$100k
NHLBI NIH HHS R01 HL148448NHLBI NIH HHS R21 HL145424NIDDK NIH HHS P30 DK079337NIDDK NIH HHS R56 DK126930
6 · The paper itself

Abstract

RATIONALE &

objectiveSince January 2017, patients with acute kidney injury requiring dialysis (AKI-D) can be discharged to outpatient dialysis centers for continued hemodialysis (HD) support. We aimed to examine the rate of kidney recovery, time to recovery, and hospitalization-related clinical parameters associated with kidney recovery in patients with AKI-D. STUDY

designSingle-center prospective cohort study. SETTING &

participants111 adult patients who were admitted to the University of Kentucky Hospital, experienced AKI-D, and were discharged with need of outpatient HD. EXPOSURE: Hospitalization-related clinical parameters were evaluated. OUTCOME: Kidney recovery as a composite of being alive and no longer requiring HD or other form of kidney replacement therapy. ANALYTICAL APPROACH: Discrete-time survival analysis and logistic regression were used to determine adjusted probabilities of kidney recovery at prespecified time points and to evaluate clinical parameters associated with recovery.

results45 (41%) patients recovered kidney function, 25 (55.5%) within the first 30 days following discharge, 16 (35.5%) within 30 to 60 days, and 4 (9%) within 60 to 90 days. Adjusted probabilities of recovery were 36.7%, 27.4%, and 6.3%, respectively. Of the remaining patients, 49 (44%) developed kidney failure requiring chronic kidney replacement therapy and 17 (15%) died or went to hospice. Patients who did not recover kidney function were older, had more comorbid conditions, had lower estimated glomerular filtration rates at baseline, and received more blood transfusions during hospitalization when compared with those who recovered kidney function. LIMITATIONS: Selection bias given that patients included in the study were all eligible for AKI management with outpatient HD as part of Medicare/Medicaid services.

conclusionsAt least one-third of AKI-D survivors discharged from an acute care hospital dependent on HD recovered kidney function within the first 90 days of discharge, more commonly in the first 30 days postdischarge. Future studies should elucidate clinical parameters that can inform risk classification and interventions to promote kidney recovery in this vulnerable and growing population.

Indexed as

acute kidney injuryAKIdialysishemodialysiskidney recoveryoutpatientrecovery

Identifiers

PMID34939001
PMCPMC8664749
OpenAlexW3193209390

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.