ArticleBioactive materials2022
The diameter factor of aligned membranes facilitates wound healing by promoting epithelialization in an immune way.
Article in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 50 citations in OpenAlex.
- Immunomodulatory cytoskeleton of bionic periosteum affects mitochondrial dynamics to promote osteogenesis.Bioactive materials · 2026Article
- Wound Geometry Determines Whether Aligned-Fiber Scaffolds Accelerate or Impede Diabetic Wound Healing: A Biased Random Walk Analysis.Advanced healthcare materials · 2026Article
- Lactoferrin as a Novel Therapeutic Agent in Dermatology: Current Evidence and Future Perspectives.Clinical, cosmetic and investigational dermatology · 2026Review
- Point-of-care treatment of acute skin wound by portable in-situ electrospinning nanofiber dressings with rapid hemostasis, anti-infection, and angiogenesis effects.Bioactive materials · 2025Article
- Nanofiber-Based Biomimetic Platforms for Chronic Wound Healing: Recent Innovations and Future Directions.Tissue engineering and regenerative medicine · 2025Review
- Aligned Electrospun PCL/PLA Nanofibers Containing Green-Synthesized CeOInternational journal of molecular sciences · 2025Article
- Electrospinning based biomaterials for biomimetic fabrication, bioactive protein delivery and wound regenerative repair.Regenerative biomaterials · 2025Review
- Exploring the antimicrobial potential of the articaine derivative in oral infections.Journal of oral microbiology · 2025Article
- Aligned nanofibers in biomimetic periosteal extracellular matrix/poly(ε-caprolactone) membranes enhance bone regeneration via the ITGB1/PI3K/AKT pathway.Regenerative biomaterials · 2025Article
- Advances and applications of biomimetic biomaterials for endogenous skin regeneration.Bioactive materials · 2024Review
- Advances and Challenges in Immune-Modulatory Biomaterials for Wound Healing Applications.Pharmaceutics · 2024Review
- Biodegradable piezoelectric skin-wound scaffold.Biomaterials · 2023Article
- Tracing immune cells around biomaterials with spatial anchors during large-scale wound regeneration.Nature communications · 2023Article
- [Research progress of biomaterials in promoting wound vascularization].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023Article
- Electrospun Hyaluronan Nanofiber Membrane Immobilizing Aromatic Doxorubicin as Therapeutic and Regenerative Biomaterial.International journal of molecular sciences · 2023Article
- Aligned electrospun poly(L-lactide) nanofibers facilitate wound healing by inhibiting macrophage M1 polarization via the JAK-STAT and NF-κB pathways.Journal of nanobiotechnology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Topographical properties, such as pattern and diameter, of biomaterials play important roles in influencing cell activities and manipulating the related immune response during wound healing. We prepared aligned electrospinning membranes with different fiber diameters, including 319 ± 100 nm (A300), 588 ± 132 nm (A600), and 1048 ± 130 nm (A1000), by adjusting the distance from the tip to the collector, the injection rate, and the concentration of the solution. The A300 membranes significantly improved cell proliferation and spreading and facilitated wound healing (epithelization and vascularization) with the regeneration of immature hair follicles compared to the other membranes. Transcriptomics revealed the underlying molecular mechanism that A300 could promote immune-related processes towards a pro-healing direction, significantly promoting keratinocyte migration and skin wound healing. All the results indicated that wound healing requires the active participation of the immune process, and that A300 was a potential candidate for guided skin regeneration applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.