Evidence map›Paper›PMID 34938855›Full record

ArticleMolecular therapy oncolytics2021

Molecular characterization of type I IFN-induced cytotoxicity in bladder cancer cells reveals biomarkers of resistance.

Jennifer L Green, Robin E Osterhout, Amy L Klova, Carsten Merkwirth, Scott R P McDonnell, Reza Beheshti Zavareh, Bryan C Fuchs, Adeela Kamal, Jørn S Jakobsen

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy oncolytics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Type I-interferon β induces a strong anti-tumour response in bladder cancer cells.Journal of cancer research and clinical oncology · 2026
    Article
  6. The emerging role of oncolytic virotherapy in genitourinary malignancies.Frontiers in cell and developmental biology · 2026
    Review
  7. Interferon-Based Therapeutics in Cancer Therapy: Past, Present, and Future.International journal of molecular sciences · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Adenovirus as a Vector and Oncolytic Virus.Current issues in molecular biology · 2023
    Review
  15. Review
  16. Article
  17. Clinical use of nadofaragene firadenovec-vncg.Therapeutic advances in urology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jennifer L GreenFerring Research Institute, San Diego, CA, USA.
Robin E OsterhoutFerring Research Institute, San Diego, CA, USA.
Amy L KlovaFerring Research Institute, San Diego, CA, USA.
Carsten MerkwirthFerring Research Institute, San Diego, CA, USA.
Scott R P McDonnellFerring Research Institute, San Diego, CA, USA.
Reza Beheshti ZavarehFerring Research Institute, San Diego, CA, USA.
Bryan C FuchsFerring Research Institute, San Diego, CA, USA.
Adeela KamalFerring Research Institute, San Diego, CA, USA.
Jørn S JakobsenFerring Pharmaceuticals, International PharmaScience Center, Copenhagen, Denmark.
Ferring Pharmaceuticals (Denmark) · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although anti-tumor activities of type I interferons (IFNs) have been recognized for decades, the molecular mechanisms contributing to clinical response remain poorly understood. The complex functions of these pleiotropic cytokines include stimulation of innate and adaptive immune responses against tumors as well as direct inhibition of tumor cells. In high-grade, Bacillus Calmette-Guérin (BCG)-unresponsive non-muscle-invasive bladder cancer, nadofaragene firadenovec, a non-replicating adenovirus administered locally to express the

Indexed as

bladder cancerconstitutive ISGIFN biomarkerIFN resistancenadofaragene firadenovecrAd-IFNα/Syn3type I interferon

Identifiers

PMID34938855
PMCPMC8645427
OpenAlexW3213156852

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.