Evidence map›Paper›PMID 34938851›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2021

The Vulnerability Index: A weighted measure of dementia and cognitive impairment risk.

Michael J Kleiman, James E Galvin

Abstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Neural embedding of frailty in cognitively unimpaired aging and dementia across Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  2. Accountable care organizations and Medicare payments for residents with ADRD in disadvantaged neighborhoods.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
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  5. Medicare Payments and ACOs for Dementia Patients Across Race and Social Vulnerability.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Michael J KleimanComprehensive Center for Brain Health Department of Neurology University of Miami Miller School of Medicine Boca Raton Florida USA.
James E GalvinComprehensive Center for Brain Health Department of Neurology University of Miami Miller School of Medicine Boca Raton Florida USA.

Funding

Multicultural Community Dementia ScreeningR01AG071514 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GALVIN, JAMES E · 2021 to 2025
$13.8M
Reducing Disparities in Dementia and VCID Outcomes in a Multicultural Rural PopulationR01NS101483 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GALVIN, JAMES E · 2019 to 2023
$8.0M
Digital Detection of Dementia Studies (D cubed Studies).R01AG069765 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI BEN-MILED, ZINA, BOUSTANI, MALAZ · 2020 to 2024
$4.9M
NIA NIH HHS R01 AG069765NIA NIH HHS R01 AG071514NINDS NIH HHS R01 NS101483
6 · The paper itself

Abstract

introductionA brief, easily calculated and interpretable index to assess vulnerability to developing cognitive impairment is needed in clinical practice and research. To address this, we developed the Vulnerability Index (VI) with the goal of identifying individuals possessing a high risk for cognitive impairment.

methodsTwelve easily obtained sociodemographic, medical, and functional factors were used to develop the VI, with each selectively weighted based on factor analysis and predictive modeling. This cross-sectional study examined 387 subject-partner dyads.

resultsThe VI was found to accurately discriminate between cognitively normal controls and participants with cognitive impairment (area under the curve [AUC]: 0.844; 95% confidence interval [CI]: 0.776-0.913) and individuals scoring high on the VI (≥8) had worse health, functional, behavioral, cognitive, and quality of life ratings than those with lower scores. DISCUSSION: The VI could be used in screening asymptomatic individuals for risk of cognitive impairment and guiding the development of primary and secondary prevention plans.

Indexed as

Alzheimer's diseasecognitive impairmentdementiafunctional assessmentshealth recordsprimary preventionrisk assessmentscreeningsociodemographics

Identifiers

PMID34938851
PMCPMC8659607

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.