Evidence map›Paper›PMID 34938821›Full record

ArticleOpen forum infectious diseases2021

Bloodstream Infection Following Cardiac Valve Repair: A Population-Based Study.

Jack W McHugh, Khawaja M Talha, Larry M Baddour, Karen M Fischer, Juan Crestanello, Arman Arghami, Daniel C DeSimone

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Infection and drug resistance · 2025
    Article
  2. Microbial Epidemiology and Antimicrobial Resistance of Bloodstream Infections in Hospitalized Patients During 2019-2023 in Xiangyang, China.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jack W McHughDepartment of Internal Medicine, Mayo Clinic School of Medicine and Science, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0002-7507-232X
Khawaja M TalhaDivision of Infectious Diseases, Department of Medicine, Mayo Clinic School of Medicine and Science, Rochester, Minnesota, USA.
Larry M BaddourDivision of Infectious Diseases, Department of Medicine, Mayo Clinic School of Medicine and Science, Rochester, Minnesota, USA.
Karen M FischerDepartment of Biomedical Statistics and Informatics, Mayo Clinic School of Medicine and Science, Rochester, Minnesota, USA.
Juan CrestanelloDivision of Cardiovascular Surgery, Mayo Clinic School of Medicine and Science, Rochester, Minnesota, USA.
Arman ArghamiDivision of Cardiovascular Surgery, Mayo Clinic School of Medicine and Science, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0002-7398-0738
Daniel C DeSimoneDivision of Infectious Diseases, Department of Medicine, Mayo Clinic School of Medicine and Science, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0002-9441-0283
Mayo Clinic · US

Funding

Interdisciplinary Infrastructure for Aging Research: Rochester Epidemiology ProjectR33AG058738 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K, OLSON, JANET E · 2020 to 2022
$2.4M
NIA NIH HHS R33 AG058738
6 · The paper itself

Abstract

backgroundThe aim of this study was to determine the incidence, epidemiology, and associated risk factors of bloodstream infection (BSI) in patients who had previously undergone cardiac valve repair.

methodsA population-based study that included 7 counties in southeastern Minnesota using the expanded Rochester Epidemiology Project (e-REP) for adults (≥18 years) who underwent valve repair between 1 January 2010 and 31 December 2018 was conducted. Electronic health records were screened for development of BSI and infective endocarditis (IE) from the date of valve repair through 30 July 2020. A 1:4 nested case-control analysis was performed to determine an association, if any, of male sex, Charlson comorbidity index (CCI), and county of residence with BSI.

resultsA total of 335 patients underwent valve repair, of whom 28 (8.3%) developed an index case of BSI, with 14 episodes occurring within 1 year of surgery. The median age of patients with BSI was 70 years, and 79% were male. The crude incidence of BSI was 1671 cases per 100000 person-years and

conclusionsThe crude incidence of BSI following valve repair was higher in our e-REP cohort than previous population-based studies, and half of the BSI cases occurred within 1 year of surgery. Patients with a higher CCI at baseline were at increased risk of subsequent BSI.

Indexed as

bloodstream infectioncardiacincidenceinfective endocarditismortalitypopulation-basedvalve repair

Identifiers

PMID34938821
PMCPMC8687125
OpenAlexW3211613540

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.