Evidence map›Paper›PMID 34938645›Full record

ArticlePlastic and reconstructive surgery. Global open2021

Methods of Sentinel Lymph Node Identification in Auricular Melanoma.

Seth Noorbakhsh, Marianna Papageorge, Renee M Maina, Raymond Baumann, Craig Moores, Sarah A Weiss, Darko Pucar, Stephan Ariyan, Kelly Olino, James Clune

Open access · goldAbstract read
In one paragraph

Article in Plastic and reconstructive surgery. Global open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Seth NoorbakhshWest Virginia University School of Medicine, Morgantown, W.V.
Marianna PapageorgeYale School of Medicine Department of Surgery;, New Haven, Conn.
Renee M MainaYale School of Medicine Department of Surgery;, New Haven, Conn.
Raymond BaumannDepartment of Pharmacology, Database Management, Yale School of Medicine, New Haven, Conn.
Craig MooresSection of Plastic and Reconstructive Surgery, Yale School of Medicine, New Haven, Conn.
Sarah A WeissSection of Medical Oncology, Yale School of Medicine, New Haven, Conn.
Darko PucarDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Conn.
Stephan AriyanSection of Plastic and Reconstructive Surgery, Yale School of Medicine, New Haven, Conn.
Kelly OlinoDepartment of Surgery, Section of Surgical Oncology, Yale School of Medicine, New Haven, Conn.
James CluneSection of Plastic and Reconstructive Surgery, Yale School of Medicine, New Haven, Conn.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
YALE CANCER CENTER CALABRESI IMMUNO-ONCOLOGY TRAINING PROGRAMK12CA215110 · NCI · YALE UNIVERSITY · PI Harriet M. Kluger · 2018 to 2026
$6.1M
NCATS NIH HHS UL1 TR001863NCI NIH HHS K12 CA215110
6 · The paper itself

Abstract

Sentinel lymph node biopsy is used to evaluate for micrometastasis in auricular melanoma. However, lymphatic drainage patterns of the ear are not well defined and predicting the location of sentinel nodes can be difficult. The goal of this study was to define the lymphatic drainage patterns of the ear and to compare multiple modalities of sentinel node identification.

methodsA retrospective review of a prospectively maintained database evaluated 80 patients with auricular melanoma who underwent sentinel lymph node biopsy by comparing preoperative imaging with intraoperative identification of sentinel nodes. Patients were placed into two cohorts, based on the modality of preoperative imaging: (1) planar lymphoscintigraphy only (n = 63) and (2) single-photon emission computerized tomography combined with computerized tomography (SPECT-CT) only (n = 17). Sites of preoperative mapping and sites of intraoperative identification were recorded as parotid/preauricular, mastoid/postauricular, and/or cervical.

resultsIn patients that underwent planar lymphoscintigraphy preoperatively (n = 63), significantly more sentinel nodes were identified intraoperatively than were mapped preoperatively in both the parotid/preauricular (

conclusionsSPECT-CT is more accurate than planar lymphoscintigraphy for the preoperative identification of draining sentinel lymph nodes in auricular melanoma. If SPECT-CT is not available, planar lymphoscintigraphy can also be used safely, but careful intraoperative evaluation, even in basins not mapped by lymphoscintigraphy, must be performed to avoid missed sentinel nodes.

Identifiers

PMID34938645
PMCPMC8687720
OpenAlexW4200312558

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.