Evidence map›Paper›PMID 34938351›Full record

ArticleComputational and mathematical methods in medicine2021

Polymorphisms in MicroRNA Genes Associated with Schizophrenia Susceptibility but Not with Effectiveness of MECT.

Danwei Zhang, Huihua Li, Kaimo Ding, Zhen Zhang, Si Luo, Guohai Li

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in Computational and mathematical methods in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Danwei ZhangDepartment of Psychiatry, Zhenjiang Mental Health Center, Zhenjiang, Jiangsu Province, China.
Huihua LiDepartment of Psychology, Zhenjiang Mental Health Center, Zhenjiang, Jiangsu Province, China.
Kaimo DingDepartment of Psychology, Zhenjiang Mental Health Center, Zhenjiang, Jiangsu Province, China.
Zhen ZhangDepartment of Psychiatry, Zhenjiang Mental Health Center, Zhenjiang, Jiangsu Province, China.
Si LuoDepartment of Psychiatry, Zhenjiang Mental Health Center, Zhenjiang, Jiangsu Province, China.
Guohai LiDepartment of Psychiatry, Zhenjiang Mental Health Center, Zhenjiang, Jiangsu Province, China.ORCID https://orcid.org/0000-0001-8334-5992

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Schizophrenia (SCZ) is a common and complex psychiatric disease associated with hereditary and environmental risk factors. MicroRNAs (miRNAs or miRs) are small, noncoding RNA molecules that endogenously regulate gene expression. Single nucleotide polymorphisms (SNPs) in related miRNA genes are associated with susceptibility of the disorder. We wonder if the SNPs have influence on the effectiveness of modified electroconvulsive therapy (MECT) for SCZ. rs1625579 within miR-137, rs6577555 within miR-34, and rs2296616 within miR-107 were sequenced in 150 cases and 150 controls to check the potential association between the SNPs and SCZ. Our results showed that allele G in rs1625579 (

Indexed as

Electroconvulsive TherapyPolymorphism, Single NucleotideAdultCase-Control StudiesComputational BiologyFemaleGenetic Predisposition to DiseaseGenotypeHumansMaleMicroRNAsMiddle AgedSchizophreniaTreatment OutcomeMicroRNAsMIRN107 microRNA, humanMIRN137 microRNA, humanMIRN34 microRNA, human

Identifiers

PMID34938351
PMCPMC8687787
OpenAlexW4200622332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.