ReviewInternational journal of endocrinology2021
The Association with Subclinical Thyroid Dysfunction and Uric Acid.
Review in International journal of endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Immune checkpoint inhibitors-related thyroid dysfunction: influencing factor analysis, prediction model development, and management strategy proposal.Cancer immunology, immunotherapy : CII · 2024Pooled it
- Observational
- Association of exposure duration, modality, and polycythaemia with hyperuricaemia among han male immigrants at high altitudes: a cross-sectional study.Annals of medicine · 2025Article
- The Relationship Between Thyroid Function Status and Serum Uric Acid Levels Based on a Restricted Cubic Spline Model: A Cross-Sectional Study.Risk management and healthcare policy · 2025Article
- Serum Uric Acid-to-Serum Creatinine Ratio, Thyroid Function, and Gestational Diabetes Mellitus Risk during Early Pregnancy among Chinese Women.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Estimation of urea, uric acid and creatinine levels in patients of primary hypothyroidism - A cross-sectional study.Journal of family medicine and primary care · 2024Article
- Uric Acid Status in Subclinical Hypothyroidism.EJIFCC · 2024Review
- Predicting thyroid involvement in primary Sjögren's syndrome: development and validation of a predictive nomogram.Frontiers in immunology · 2024Article
- Gender-specific association between blood cell parameters and hyperuricemia in high-altitude areas.Frontiers in public health · 2024Article
- Uric Acid Metabolic Disorders in Pituitary-Target Gland Axis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
- Analysis of Subclinical Thyroid Dysfunction and Metabolic Abnormality in 28568 Healthy People.International journal of endocrinology · 2023Article
- Plasma Metabolomics Reveals Systemic Metabolic Alterations of Subclinical and Clinical Hypothyroidism.The Journal of clinical endocrinology and metabolism · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between subclinical thyroid dysfunction and uric acid was not well established. This study aimed to determine if subclinical thyroid dysfunction is associated with hyperuricemia risk and to evaluate the levels of uric acid in patients with different forms of subclinical thyroid dysfunction. A systematic search was conducted in 4 databases to obtain relevant studies on subclinical thyroid dysfunction (subclinical hyperthyroidism and subclinical hypothyroidism) and uric acid. The standardized mean difference (SMD) or odds ratio (OR) and 95% confidence interval (95% CI) were used for evaluation, and the sensitivity analysis was conducted. Publication bias was estimated by funnel plot, Egger's test, and Begg's test. A total of 73 studies were included in this meta-analysis. The results demonstrated that serum levels of uric acid in patients with subclinical hypothyroidism were significantly higher than those of controls and patients with subclinical hyperthyroidism. Patients with subclinical thyroid dysfunction had a higher prevalence of hyperuricemia compared with normal clinical thyroid function. Subclinical thyroid dysfunction was associated with the prevalence of hyperuricemia. Different types of subclinical thyroid dysfunction had varied effects on serum levels of uric acid.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.