Evidence map›Paper›PMID 34938281›Full record

ArticleFrontiers in microbiology2021

FtsZ-Ring Regulation and Cell Division Are Mediated by Essential EzrA and Accessory Proteins ZapA and ZapJ in

Amilcar J Perez, Jesus Bazan Villicana, Ho-Ching T Tsui, Madeline L Danforth, Mattia Benedet, Orietta Massidda, Malcolm E Winkler

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. [Advances in the Regulation of Protein Phosphorylation in Streptococcal Cell Wall Synthesis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Elongasome core proteins and class A PBP1a display zonal, processive movement at the midcell ofProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. The Pneumococcal Divisome: Dynamic Control ofFrontiers in microbiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Amilcar J PerezDepartment of Biology, Indiana University Bloomington, Bloomington, IN, United States.
Jesus Bazan VillicanaDepartment of Biology, Indiana University Bloomington, Bloomington, IN, United States.
Ho-Ching T TsuiDepartment of Biology, Indiana University Bloomington, Bloomington, IN, United States.
Madeline L DanforthDepartment of Biology, Indiana University Bloomington, Bloomington, IN, United States.
Mattia BenedetDepartment of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy.
Orietta MassiddaDepartment of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy.
Malcolm E WinklerDepartment of Biology, Indiana University Bloomington, Bloomington, IN, United States.
Indiana University Bloomington · USUniversity of Trento · IT

Funding

New Regulatory Interactions and Circuits that Mediate the Dynamics, Homeostasis, and Stress Responses of Peptidoglycan Synthesis in the Superbug Streptococcus pneumoniaeR35GM131767 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI MALCOLM E. WINKLER · 2019 to 2026
$4.8M
Graduate Program in Quantitative and Chemical Biology at Indiana University BloomT32GM109825 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI GIEDROC, DAVID P. · 2014 to 2018
$926k
NIGMS NIH HHS R35 GM131767NIGMS NIH HHS T32 GM109825
6 · The paper itself

Abstract

The bacterial FtsZ-ring initiates division by recruiting a large repertoire of proteins (the divisome; Z-ring) needed for septation and separation of cells. Although FtsZ is essential and its role as the main orchestrator of cell division is conserved in most eubacteria, the regulators of Z-ring presence and positioning are not universal. This study characterizes factors that regulate divisome presence and placement in the ovoid-shaped pathogen,

Indexed as

EzrA functionFtsZ-ring formationlocalization of peptidoglycan synthesisMapZ(LocZ)SepFZapAZapJ (Spd_1350)

Identifiers

PMID34938281
PMCPMC8687745
OpenAlexW4200363183

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.