ArticleFrontiers in neurology2021
Improving Diagnosis and Prognosis in Acute Severe Brain Injury: A Multimodal Imaging Protocol.
Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Neuroimaging Insights into the Public Health Burden of Neuropsychiatric Disorders: A Systematic Review of Electroencephalography-Based Cognitive Biomarkers.Medicina (Kaunas, Lithuania) · 2025Pooled it
- EEG functional connectivity measures for differentiating 6-month consciousness-related outcome after brain injury.BMC medical imaging · 2026Article
- Early Identification of Recovery Potential After Acute Brain Injury Using Functional Near-Infrared Spectroscopy.Neurocritical care · 2026Article
- Detecting Awareness in the Intensive Care Unit Using Functional Near-Infrared Spectroscopy.Annals of neurology · 2025Article
- Functional neuroimaging in disorders of consciousness: towards clinical implementation.Brain : a journal of neurology · 2025Review
- Parallel EEG-fNIRS assessments of covert cognition in behaviorally non-responsive ICU patients: A multi-task feasibility study in a case of acute motor sensory axonal neuropathy.Journal of neurology · 2025Article
- Functional near-infrared spectroscopy for the assessment and treatment of patients with disorders of consciousness.Frontiers in neurology · 2025Review
- Functional near-infrared spectroscopy: A novel tool for detecting consciousness after acute severe brain injury.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Improved clinical outcome prediction in depression using neurodynamics in an emotional face-matching functional MRI task.Frontiers in psychiatry · 2024Article
- Assessing the consistency and sensitivity of the neural correlates of narrative stimuli using functional near-infrared spectroscopy.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Differences in the effect of repetitive transcranial magnetic stimulation and median nerve electrical stimulation in patients with prolonged disorders of consciousness after intracerebral hemorrhage: a randomized controlled trial protocol.Frontiers in neurology · 2024Article
- Covert consciousness.NeuroRehabilitation · 2024Article
- Predicting neurologic recovery after severe acute brain injury using resting-state networks.Journal of neurology · 2023Article
- Revealing the spatiotemporal requirements for accurate subject identification with resting-state functional connectivity: a simultaneous fNIRS-fMRI study.Neurophotonics · 2023Article
- Effects of Systemic Physiology on Mapping Resting-State Networks Using Functional Near-Infrared Spectroscopy.Frontiers in neuroscience · 2022Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multi-modal neuroimaging techniques have the potential to dramatically improve the diagnosis of the level consciousness and prognostication of neurological outcome for patients with severe brain injury in the intensive care unit (ICU). This protocol describes a study that will utilize functional Magnetic Resonance Imaging (fMRI), electroencephalography (EEG), and functional Near Infrared Spectroscopy (fNIRS) to measure and map the brain activity of acute critically ill patients. Our goal is to investigate whether these modalities can provide objective and quantifiable indicators of good neurological outcome and reliably detect conscious awareness. To this end, we will conduct a prospective longitudinal cohort study to validate the prognostic and diagnostic utility of neuroimaging techniques in the ICU. We will recruit 350 individuals from two ICUs over the course of 7 years. Participants will undergo fMRI, EEG, and fNIRS testing several times over the first 10 days of care to assess for residual cognitive function and evidence of covert awareness. Patients who regain behavioral awareness will be asked to complete web-based neurocognitive tests for 1 year, as well as return for follow up neuroimaging to determine which acute imaging features are most predictive of cognitive and functional recovery. Ultimately, multi-modal neuroimaging techniques may improve the clinical assessments of patients' level of consciousness, aid in the prediction of outcome, and facilitate efforts to find interventional methods that improve recovery and quality of life.
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