ArticleReproductive medicine and biology2022
Higher fibrotic content of endometriotic lesions is associated with diminished prostaglandin E2 signaling.
Article in Reproductive medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- The role of fibrosis in endometriosis: a systematic review.Human reproduction update · 2024Pooled it
- Metabolic remodeling of endometriosis microenvironment: Energy stress and immune evasion.iScience · 2026Review
- Exploring endometriosis through 3DMaterials today. Bio · 2026Review
- Hormonal Dysregulation and Neuroinflammation in Endometriosis: Convergent Druggable Pathways.Current issues in molecular biology · 2026Review
- Progressively Diminished Prostaglandin E2 Signaling in Concordance with Increasing Fibrosis in Ectopic Endometrium.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Artificial intelligence-based tissue segmentation and cell identification in multiplex-stained histological endometriosis sections.Human reproduction (Oxford, England) · 2025Article
- Progressively diminished estrogen signaling concordant with increased fibrosis in ectopic endometrium.Human reproduction open · 2025Article
- Patterns of proliferation and fibrosis in a rat model of endometriosis following administration of Allium cepa.Clinical and experimental reproductive medicine · 2024Article
- Digestive system deep infiltrating endometriosis: What do we know.Journal of cellular and molecular medicine · 2023Review
- The Role of Platelets in the Pathogenesis and Pathophysiology of Adenomyosis.Journal of clinical medicine · 2023Review
- Utility of the Levonorgestrel-Releasing Intrauterine System in the Treatment of Abnormal Uterine Bleeding and Dysmenorrhea: A Narrative Review.Journal of clinical medicine · 2022Article
- Changing prostaglandin E2 (PGEReproductive medicine and biology · 2022Article
- Squeezing the eggs to grow: The mechanobiology of mammalian folliculogenesis.Frontiers in cell and developmental biology · 2022Review
- Higher fibrotic content of endometriotic lesions is associated with diminished prostaglandin E2 signaling.Reproductive medicine and biology · 2022Article
- Aberrant expression of histone deacetylase 8 in endometriosis and its potential as a therapeutic target.Reproductive medicine and biologyArticle
- How does the extent of fibrosis in adenomyosis lesions contribute to heavy menstrual bleeding?Reproductive medicine and biologyArticle
- Corroborating evidence for aberrant expression of histone deacetylase 8 in endometriosis.Reproductive medicine and biologyArticle
- Age-dependent phenotypes of ovarian endometriomas.Reproductive medicine and biologyReview
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWhile the prevailing view holds that the prostaglandin E2 (PGE
methodsImmunohistochemistry analysis of COX-2, EP2, and EP4, along with the quantification of lesional fibrosis, was conducted for OE and DE lesion samples and also OE lesion samples from adolescent and adult patients. The effect of substrate rigidity on fibroblast-to-myofibroblast transdifferentiation (FMT) and the expression of COX-2, EP2, and EP4, with or without TGF-β1 stimulation, were investigated.
resultsThe immunostaining of COX-2, EP2, and EP4 was substantially reduced in endometriotic lesions as lesions became more fibrotic. Both TGF-β1 stimulation and stiff substrates induced FMT and reduced the expression of COX-2, EP2, and EP4.
conclusionsSince fibrosis is a common feature of endometriosis, our results thus cast doubts on the use of therapeutics that suppresses the PGE
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