ArticleReproductive medicine and biology2022
Clinical outcome of intrauterine infusion of platelet-rich plasma in patients with recurrent implantation failure.
Article in Reproductive medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Effects of autologous platelet-rich plasma in recurrent implantation failure: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Evolution of biotechnological advances and regenerative therapies for endometrial disorders: a systematic review.Human reproduction update · 2024Pooled it
- Platelet-rich plasma as an adjuvant therapy for intrauterine adhesions: a narrative review of mechanisms, clinical efficacy and combination strategies.Annals of medicine · 2026Review
- Platelet-Rich Plasma in Recurrent Pregnancy Loss: Toward a Precision Medicine Framework for Biologically Guided Patient Selection.Medical sciences (Basel, Switzerland) · 2026Review
- The application of tissue engineering strategies for uterine regeneration.Materials today. Bio · 2025Review
- The effect of endometrial PRP on fertility outcomes in women with implantation failure or thin endometrium.Archives of gynecology and obstetrics · 2025Article
- Review
- The Effect of Autologous Platelet Rich Plasma on Endometrial Receptivity: A Narrative Review.Medicina (Kaunas, Lithuania) · 2025Review
- Impact of platelet-rich plasma intrauterine perfusion on endometrial receptivity and pregnancy outcomes in patients with recurrent implantation failure and thin endometrium.American journal of translational research · 2025Article
- The effect of autologous platelet-rich plasma intrauterine perfusion on pregnancy outcomes of frozen-thawed embryo transfer in patients with chronic endometritis.Frontiers in reproductive health · 2025Article
- Efficacy of intrauterine autologous blood cell derivatives in enhancing endometrial thickness and IVF outcomes for women with recurrent implantation failure: a retrospective cohort study.Journal of assisted reproduction and genetics · 2024Article
- Value of Intrauterine Autologous Platelet-Rich Plasma Therapy on Endometrial Receptivity: A Literature Review.Current medical science · 2023Review
- A study on the preoperative risk factors for primary healing failure in the reconstruction of deep sternal wound infection with platelet-rich plasma and negative pressure trauma therapy.International wound journal · 2023Article
- Factors Affecting the Potential Efficacy of Intrauterine Platelet-Rich Plasma Infusion on Thin Endometrium in Women with Recurrent Implantation Failure.Journal of personalized medicine · 2023Article
- Intrauterine Infusion of Leukocyte-Poor Platelet-Rich Plasma Is an Effective Therapeutic Protocol for Patients with Recurrent Implantation Failure: A Retrospective Cohort Study.Journal of clinical medicine · 2023Article
- ESHRE good practice recommendations on recurrent implantation failure.Human reproduction open · 2023Article
- Clinical outcome of intrauterine infusion of platelet-rich plasma in patients with recurrent implantation failure.Reproductive medicine and biology · 2022Article
- The number of previous implantation failures is a critical determinant of intrauterine autologous platelet-rich plasma infusion success in women with recurrent implantation failure.Reproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to evaluate the effectiveness of intrauterine infusion of platelet-rich plasma (PRP) before embryo transfer (ET) in recurrent implantation failure (RIF) cases.
methodsThe authors retrospectively analyzed 54 ET cycles involving frozen and thawed high-quality blastocysts after intrauterine PRP infusion between September 2019 and November 2020. All patients had a history of at least two times of implantation failure on ET. A total of 54 patients were categorized into two groups: thin endometrium (39 patients) and unexplained implantation failure (15 patients). In the thin-endometrium group, the endometrial thickness (EMT) was <8.0 mm at cycle days 12-14 in the prior ET cycle.
resultsAmong the 54 ET cycles after PRP infusion, 31 (57.4%) were positive for human chorionic gonadotropin (hCG) and 27 (50%) achieved clinical pregnancy, which was significantly better than that in prior ET cycles without PRP infusion (27.2% and 9.6%, respectively). The EMT was not increased at ET date on the PRP cycle compared with that in the prior ET cycle in both patient groups. Moreover, EMT was not different between the hCG-positive and hCG-negative groups.
conclusionAlthough intrauterine PRP infusion had no superior effect on increasing the EMT than conventional therapeutic agents, it resulted in high pregnancy rates in patients experiencing RIF with or without thin endometrium.
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