ReviewInfection and drug resistance2021
Anthelmintic Resistance and Its Mechanism: A Review.
Review in Infection and drug resistance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
120 citing papers in PubMed, 2 syntheses or guidelines pooled it, 228 citations in OpenAlex.
- Anthelmintic resistance in livestock in Africa: review of the current status.BMC veterinary research · 2025Pooled it
- Livestock and avermectins in sub-Saharan Africa: a restricted systematic review of the impacts on productivity and documentation of resistance.Parasitology · 2025Pooled it
- Multiple anthelmintic resistance in Haemonchus contortus infecting sheep in Gangetic plains of India.Tropical animal health and production · 2026Article
- Naringenin mitigates experimental Trichinella spiralis infection in in vitro and in vivo studies.Scientific reports · 2026Article
- Deep phenotypic profiling uncovers cryptic effects of antifilarial drugs.PLoS pathogens · 2026Article
- Preliminary survey of anthelmintic efficacy in selected smallholder sheep and goat flocks in Sarawak, Malaysia.Tropical animal health and production · 2026Article
- Anthelmintic resistance in gastrointestinal nematodes of small ruminants in Southern Africa: a review and comparative analysis.Veterinary research communications · 2026Review
- Spotlighting zoonotic strongyloidiasis: a semi-systematic review of threadworms within baboons highlights opportunities for human infections.Infectious diseases of poverty · 2026Review
- Genotypic evidence of benzimidazole resistance and population structure insights in zoonotic Trichostrongylus colubriformis from Thailand.Parasitology research · 2026Article
- Exploratory Evaluation ofVeterinary sciences · 2026Article
- The Role of Natural Anthelmintics in Small Ruminant Health: A Global Narrative Review.Animals : an open access journal from MDPI · 2026Review
- Perceptions on the Economic Feasibility of Sustainable Roundworm Control Practices in Grazed Livestock-A Short Survey Among European Farmers and Veterinarians.Animals : an open access journal from MDPI · 2026Article
- Biotransformation of obefazimod, a novel potential anthelmintic, in sheep and the target nematode Haemonchus contortus.Scientific reports · 2026Article
- A practical miracidial motility assay for assessing Fasciola hepatica sensitivity to compounds in vitro.International journal for parasitology. Drugs and drug resistance · 2026Article
- Cloning, expression and characterisation of short-chain dehydrogenase/reductase SDR12 (A0A7I5E7J1) from a parasitic nematode Haemonchus contortus.Scientific reports · 2026Article
- Unveiling of phytochemicals, antioxidants, cytotoxic effects and anthelmintic potency of green tea (Camellia sinensis) beverage against albendazole resistant Hamonchus contortus.Scientific reports · 2026Article
- Life Stage-Specific Burdens and Impacts of Gastrointestinal Nematodes in Beef Cattle in the United States: A Review of Diagnostics, Impacts on Productivity, and Immune Response.Veterinary sciences · 2026Review
- Deep phenotypic profiling uncovers cryptic effects of antifilarial drugs.bioRxiv : the preprint server for biology · 2026Article
- Anthelmintic Activity of Protocatechuic Acid Against Ivermectin-Susceptible and ResistantPathogens (Basel, Switzerland) · 2026Article
- Nematicidal indole oxazoles and chemoattractants from soil bacteria.bioRxiv : the preprint server for biology · 2026Article
60 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helminths are a various types of parasites causing a major health problem for animals in different parts of the globe. Control of helminthiasis has largely relied on the use of pharmaceutical anthelmintics. Unfortunately, the exhaustive use of anthelmintic drugs has led to a serious and dramatic level of anthelmintic resistance. Anthelmintic resistance is a heritable loss of sensitivity of an anthelmintic in a parasite population that was in the past susceptible to the same anthelmintic. The development of anthelmintic resistance is evident to different helminths of almost every animal species and to different groups of anthelmintic in several continents. Frequent treatment, underdosing, genetics of the parasite, and targeting and timing of mass treatment are predisposing factors for anthelmintic resistance. Upregulation of cellular efflux mechanisms, an increase in drug metabolism, a change in drug receptor sites that reduces drug binding or the functional consequences of drug binding, and a decrease in drug receptor abundance through reduced expression within the parasite are the main mechanisms of anthelmintic resistance. In vivo method like fecal egg count reduction test and in vitro method such as egg hatch assays, larval motility test, larval development test and PCR can be used for the detection of anthelmintic resistance. Proper utilization of anthelmintic drugs, using combined anthelmintic and applying other alternatives are essential strategies to slow down the development of anthelmintic resistance. As anthelmintic resistance is a serious challenge throughout the world, proper utilization of the existing anthelmintics and reducing dependence on anthelmintics should be implemented to reduce its challenge.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.