ArticleNeuropsychiatric disease and treatment2021
Well-Water Consumption and Risk of Parkinson's Disease: A Meta-Analysis of 15 Observational Studies.
Article in Neuropsychiatric disease and treatment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Environmental determinants of Parkinson's disease and attributable burden in Latin America.Research square · 2026Article
- Risk and protective factors in Parkinson's disease: a simultaneous and prospective study with classical statistical and novel machine learning models.Journal of neurology · 2023Article
- Dietary and Environmental Risk Factors in Parkinson's Disease and Alzheimer's Disease: Beware of Your Food Plate and Your Surroundings!Annals of Indian Academy of NeurologyArticle
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe relationship between the risk of Parkinson disease and well-water consumption has been extensively studied, but the results have been contradictory. Therefore, we conducted a meta-analysis of observational studies to systematically assess the relationship between well-water consumption and Parkinson disease risk.
methodsWe followed the PRISMA checklist in completing the meta-analysis. We searched two electronic databases (PubMed, EBSCO, EMBASE and Cochrane) from establishment to October, 2021, to identify relevant studies linking well-water drinking to Parkinson risk. We used a random-effects model to calculate the overall odds ratio (OR) with 95% confidence interval (CI). To reduce intragroup heterogeneity, we conducted subgroup analyses according to the research design and geographic area.
resultsAfter careful review, a total of 15 case-control-designed studies included data suitable for our meta-analysis. The total number of cases and total controls that contribute to the combined OR were 2182 and 2456. The combined OR for ever well-water drinkers versus non-drinkers was 1.16 (95% CI: 0.97-1.39, I DISCUSSION: Our results indicate that there is no significant correlation between well-water consumption and PD risk.
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Registered trials
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