ArticleBiology of sport2021
Caffeine mouth rinse enhances performance, fatigue tolerance and reduces muscle activity during moderate-intensity cycling.
Article in Biology of sport, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Revisiting the evidence on caffeine mouth rinse: effects on exercise and cognitive performance: a meta-analytic review.Journal of the International Society of Sports Nutrition · 2026Pooled it
- Effects of carbohydrate, caffeine and menthol mouth rinses on exercise performance and ratings of perceived exertion: a systematic review and network meta-analysis.Frontiers in nutrition · 2026Pooled it
- Effects of Menthol Mouth Rinsing on Performance and Surface EMG Activity During Heat-Stressed Cycling.Nutrients · 2026Trial
- Are caffeine effects equivalent between different modes of administration: the acute effects of 3 mg.kgJournal of the International Society of Sports Nutrition · 2024Trial
- Repeated mouth rinsing of coffee improves the specific-endurance performance and jump performance of young male futsal players.Journal of the International Society of Sports Nutrition · 2023Trial
- Trial
- High-Dose Caffeine Mouth Rinse Is an Effective Strategy for Isokinetic Strength Generation in Soccer Players.Journal of human kinetics · 2026Article
- Review
- The effect of caffeine, nap opportunity and their combination on biomarkers of muscle damage and antioxidant defence during repeated sprint exercise.Biology of sport · 2022Article
- Caffeine-carbohydrate mouth-rinsing counter-acts an observed negative effect of mouth-rinsing procedure during sprint-endurance training performance in fasted athletes: A pilot study.Biology of sport · 2022Article
- Effects of caffeinated beverage ingestion on salivary antimicrobial proteins responses to acute exercise in the heat.Frontiers in nutrition · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the effects of caffeine mouth rinse on endurance performance, muscle recruitment (i.e., electromyographic activity of the vastus lateralis and rectus femoris), rating of perceived effort and heart rate. Twelve physically-active healthy men cycled at 80% of their respiratory compensation point until task failure. The participants rinsed their mouths for 10 seconds with placebo (PLA, 25 mL of a solution composed of non-caloric mint essence) or caffeine (CAF, 25 mL of 1.2% of anhydrous caffeine concentration with non-caloric mint essence) every 15 minutes of exercise. Time until exhaustion increased 17% (effect size = 0.70) in CAF compared to PLA (p = 0.04). The wavebands of low-frequency electromyographic activity (EMG) of the vastus lateralis and rectus femoris was lower in CAF group than PLA at 50% of the time until exhaustion (p = 0.04). The global EMG signal was lower in CAF group than PLA at 100% of the time until exhaustion (p = 0.001). The rating of perceived effort pooled was higher in CAF mouth rinse (p = 0.001) than PLA group. No effect was found on the heart rate between the groups (p > 0.05). Caffeine mouth rinse increases endurance performance, rating of perceived effort and decreases muscle activity during a moderate-intensity exercise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.