Evidence map›Paper›PMID 34937938›Full record

ArticleNature2022

Cancer risk across mammals.

Orsolya Vincze, Fernando Colchero, Jean-Francois Lemaître, Dalia A Conde, Samuel Pavard, Margaux Bieuville, Araxi O Urrutia, Beata Ujvari, Amy M Boddy, Carlo C Maley and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed, 1 pooled it
32.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

135 citing papers in PubMed, 1 synthesis or guideline pooled it, 233 citations in OpenAlex.

  1. Susceptibility ofTechnology in cancer research & treatment
    Pooled it
  2. Review
  3. Article
  4. Review
  5. Indirect genomic effects shape cancer risk across species.bioRxiv : the preprint server for biology · 2026
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  6. Article
  7. Review
  8. Article
  9. Mammalian evolution and human mutation burden in Rab GTPases.Biochemistry and biophysics reports · 2026
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  10. Review
  11. Article
  12. Burn Selection: How Fire Injury Shaped Human Evolution.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Stromal resistance to placental invasion is a derived trait in ruminants.The Journal of reproduction and development · 2026
    Review
  20. Mortality burden of malignant neoplasms of the corpus uteri in Mexico: an analysis of trends from 2000 to 2022.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2026
    Article

75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 9 countries.

Orsolya VinczeCREEC/CANECEV, MIVEGEC (CREES), University of Montpellier, CNRS, IRD, Montpellier, France. vincze.orsolya@ecolres.hu.ORCID http://orcid.org/0000-0001-5789-2124
Fernando ColcheroDepartment of Mathematics and Computer Science, University of Southern Denmark, Odense, Denmark.ORCID http://orcid.org/0000-0001-8613-4568
Jean-Francois LemaîtreLaboratoire de Biométrie et Biologie Evolutive, Université de Lyon, Université Lyon 1; CNRS,UMR5558, Villeurbanne, France.
Dalia A CondeInterdisciplinary Centre on Population Dynamics, University of Southern Denmark, Odense, Denmark.ORCID http://orcid.org/0000-0002-7923-8163
Samuel PavardEco-Anthropologie (EA), Muséum National d'Histoire Naturelle, CNRS, Université de Paris, Musée de l'Homme, Paris, France.
Margaux BieuvilleEco-Anthropologie (EA), Muséum National d'Histoire Naturelle, CNRS, Université de Paris, Musée de l'Homme, Paris, France.
Araxi O UrrutiaInstituto de Ecologia, UNAM, Mexico City, Mexico.
Beata UjvariCentre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Geelong, Victoria, Australia.ORCID http://orcid.org/0000-0003-2391-2988
Amy M BoddyDepartment of Anthropology, University of California Santa Barbara, Santa Barbara, CA, USA.
Carlo C MaleyArizona Cancer Evolution Center, Biodesign Institute and School of Life Sciences, Arizona State University, Tempe, AZ, USA.ORCID http://orcid.org/0000-0002-0745-7076
Frédéric ThomasCREEC/CANECEV, MIVEGEC (CREES), University of Montpellier, CNRS, IRD, Montpellier, France.ORCID http://orcid.org/0000-0003-2238-1978
Mathieu GiraudeauCREEC/CANECEV, MIVEGEC (CREES), University of Montpellier, CNRS, IRD, Montpellier, France.
Centre National de la Recherche Scientifique · FRUniversity of Southern Denmark · DKArizona State University · USDeakin University · AUInstituto de Ecología · MXUniversité Claude Bernard Lyon 1 · FRUniversity of California, Santa Barbara · US

Funding

Molecular, Cellular and Tissue Characterization UnitU2CCA233254 · NCI · DUKE UNIVERSITY · PI HWANG, E.SHELLEY, MALEY, CARLO · 2018 to 2023
$11.4M
The Role of the Microbiome in Cancer Suppression and Susceptibility Across SpeciesU54CA217376 · NCI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI MALEY, CARLO · 2018 to 2022
$8.6M
NCI NIH HHS U2C CA233254NCI NIH HHS U54 CA217376
6 · The paper itself

Abstract

Cancer is a ubiquitous disease of metazoans, predicted to disproportionately affect larger, long-lived organisms owing to their greater number of cell divisions, and thus increased probability of somatic mutations

Indexed as

Animals, ZooDietMammalsNeoplasmsAgingAnimalsBody SizeBody WeightCarnivoryLongevityPhylogenyRisk FactorsSpecies Specificity

Identifiers

PMID34937938
PMCPMC8755536
OpenAlexW4200048313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.