ArticleNature nanotechnology2022
Full-bandwidth electrophysiology of seizures and epileptiform activity enabled by flexible graphene microtransistor depth neural probes.
Article in Nature nanotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 108 citations in OpenAlex.
- A freestanding submicron electrocorticography electrode array.Nature communications · 2026Article
- The Application of Flexible Graphene Field-Effect Transistor Sensors in Multidimensional Biosensing and Precision Medicine.Materials (Basel, Switzerland) · 2026Review
- Dual role of spreading depolarization in an epileptic focus.Epilepsia · 2026Article
- An artefact-resilient wide bandwidth bidirectional graphene neural interface.Nature communications · 2026Article
- Mitigating Interfacial Contamination for Scalable Integration of Graphene in Neuroelectronic Devices.Accounts of materials research · 2026Article
- Cortical spreading depolarizations in stroke: Mechanisms, neuroprotective interventions, and monitoring techniques.GeroScience · 2026Review
- "Tone-Arm" Neuromodulation MEMS Microcoil for In Vivo Imaging.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Nanophotonic neural probes for in vivo photostimulation, electrophysiology, and microfluidic delivery.Microsystems & nanoengineering · 2026Article
- Multimodal Layer-Crossing Interrogation of Brain Circuits Enabled by Microfluidic Axialtrodes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Flexible two-dimensional neural sensors.Nature materials · 2026Article
- Multi-Channel Neural Interface for Neural Recording and Neuromodulation.Small methods · 2026Review
- Pentylenetetrazole kindling impairs place recognition memory associated with suppressing proBDNF-mediated neural information flows at the hippocampal CA3-CA1 synapses.Frontiers in pharmacology · 2026Article
- Data driven multiscale modelling of paroxysmal brain transitions using DC-coupled electrophysiological data.PloS one · 2026Article
- Neural vs Neuromorphic Interfaces: Where Are We Standing?Chemical reviews · 2025Review
- An Implantable, Ultralow Distortion Bioelectronic Interface Integrating Light-Emitting Diodes and Graphene Field-Effect Transistors.ACS nano · 2025Article
- Article
- Micro-Coil Neuromodulation at Single-Cell and Circuit Levels for Inhibiting Natural Neuroactivity, Neutralizing Electric Neural Excitation, and Suppressing Seizures.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Flexible Deep-Brain Probe for High-Fidelity Multi-Scale Recording of Epileptic Network Dynamics.Micromachines · 2025Article
- The role of electroencephalography in epilepsy research-From seizures to interictal activity and comorbidities.Epilepsia · 2025Review
- Review
Corrections and comments
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Authors and funding
28 authors at 8 institutions in 3 countries.
Funding
Abstract
Mapping the entire frequency bandwidth of brain electrophysiological signals is of paramount importance for understanding physiological and pathological states. The ability to record simultaneously DC-shifts, infraslow oscillations (<0.1 Hz), typical local field potentials (0.1-80 Hz) and higher frequencies (80-600 Hz) using the same recording site would particularly benefit preclinical epilepsy research and could provide clinical biomarkers for improved seizure onset zone delineation. However, commonly used metal microelectrode technology suffers from instabilities that hamper the high fidelity of DC-coupled recordings, which are needed to access signals of very low frequency. In this study we used flexible graphene depth neural probes (gDNPs), consisting of a linear array of graphene microtransistors, to concurrently record DC-shifts and high-frequency neuronal activity in awake rodents. We show here that gDNPs can reliably record and map with high spatial resolution seizures, pre-ictal DC-shifts and seizure-associated spreading depolarizations together with higher frequencies through the cortical laminae to the hippocampus in a mouse model of chemically induced seizures. Moreover, we demonstrate the functionality of chronically implanted devices over 10 weeks by recording with high fidelity spontaneous spike-wave discharges and associated infraslow oscillations in a rat model of absence epilepsy. Altogether, our work highlights the suitability of this technology for in vivo electrophysiology research, and in particular epilepsy research, by allowing stable and chronic DC-coupled recordings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.