Observational studyNature immunology2022
Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8
Registry-linked trialOpen access · bronzeAbstract readObservational Study
In one paragraph
Observational study in Nature immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05560906 (Study of Virus-specific Lymphocytic Cell Populations in Non-invasive Nasal Mucosa Samples of MIS-C Patients, and Intra-population Shifts in Inflammatory Tissues in the Acute Phase of MIS-C and in Health), which is not on this map. Cited by 85 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of Virus-specific Lymphocytic Cell Populations in Non-invasive Nasal Mucosa Samples of MIS-C Patients, and Intra-population Shifts in Inflammatory Tissues in the Acute Phase of MIS-C and in Health
Who cites it
85 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.
- AGA Clinical Practice Update on Esophageal Dysfunction Due to Disordered Immunity and Infection: Expert Review.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024Guideline
- Review
- Utility of Nasopharyngeal Aspirate Over Other Upper Airway Sampling Approaches for Cellular Immunology During Respiratory Viral Infection.The Journal of infectious diseases · 2026Article
- T-cell receptor repertoires against HLA class I-restricted minor histocompatibility antigens are highly diverse with a small subset of public clonotypes.Journal for immunotherapy of cancer · 2026Article
- The Role of CD4 T Cell Repertoire and Immune Memory Mechanisms in Vaccination and Infection Immunity.Immunological reviews · 2026Review
- Harnessing mucosal immunity for protective vaccines.Nature reviews. Immunology · 2026Review
- Immunological memory to vaccines.Immunity · 2026Review
- Olfactory immunity: defending the neural-mucosal barrier.Journal of immunology (Baltimore, Md. : 1950) · 2026Review
- A Paediatric Perspective: Opportunities and Challenges in Emergency Department Antimicrobial Stewardship.Antibiotics (Basel, Switzerland) · 2026Review
- Key messengers in the gut-nose axis: mechanisms of gut microbial metabolites in the immunomodulation of allergic rhinitis.Frontiers in immunology · 2026Review
- Tissue-resident memory T cells reshapeFrontiers in immunology · 2026Review
- scRNA-seq reveals persistent aberrant differentiation of nasal epithelium driven by TNFα and TGFβ in post-COVID syndrome.Nature communications · 2025Article
- Limited nasal IFN production contributes to delayed respiratory virus clearance and suboptimal vaccine responses.JCI insight · 2025Article
- Lung-resident memory Th2 cells regulate pulmonary cryptococcosis by inducing type-II granuloma formation.Mucosal immunology · 2025Article
- Role of antiviral CD8+ T cell immunity to SARS-CoV-2 infection and vaccination.Journal of virology · 2025Review
- Tissue-Resident Memory CD8+ T Cells: Differentiation, Phenotypic Heterogeneity, Biological Function, Disease, and Therapy.MedComm · 2025Review
- Robust mucosal SARS-CoV-2-specific T cells effectively combat COVID-19 and establish polyfunctional resident memory in patient lungs.Nature immunology · 2025Article
- Temporal profiling of human lymphoid tissues reveals coordinated defense against viral challenge.Nature immunology · 2025Article
- Exploration of the plasma proteomic profile of patients at risk of thromboembolic events.Research and practice in thrombosis and haemostasis · 2025Article
- KLRB1 expression in nasopharyngeal mucosa as a prognostic biomarker in COVID-19 patients.Scientific reports · 2025Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors at 2 institutions in 1 country.
Anna H E RoukensDepartment of Infectious Diseases, Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-1397-0992
Cilia R Pothast *Department of Hematology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-9761-3123
Marion König *Department of Parasitology, Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-9892-218X
Wesley Huisman *Department of Parasitology, Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-5699-7087
Tim DaleboutDepartment of Medical Microbiology, Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-5916-7548
Tamar TakDepartment of Parasitology, Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-5959-7927
Shohreh AzimiDepartment of Parasitology, Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-3117-5722
Yvonne KruizeDepartment of Parasitology, Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Renate S HagedoornDepartment of Hematology, Leiden University Medical Center, Leiden, the Netherlands.
Mihaela ZleiDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-6865-8883
Frank J T StaalDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0003-1588-8519
Fenna J de BieDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0003-3817-8616
Jacques J M van DongenDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-3650-7087
Sesmu M ArbousDepartment of Intensive Care, Leiden University Medical Center, Leiden, the Netherlands.
Jaimie L H ZhangDepartment of Infectious Diseases, Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0003-3064-5486
Maaike VerheijDepartment of Infectious Diseases, Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0001-9686-3676
Corine PrinsDepartment of Infectious Diseases, Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Anne M van der DoesDepartment of Pulmonology, Leiden University Medical Center, Leiden, the Netherlands.
Pieter S HiemstraDepartment of Pulmonology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-0238-5982
Jutte J C de VriesDepartment of Medical Microbiology, Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Jacqueline J JanseDepartment of Parasitology, Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0003-4884-5881
Meta RoestenbergDepartment of Infectious Diseases, Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-5052-2830
Sebenzile K MyeniDepartment of Medical Microbiology, Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Marjolein KikkertDepartment of Medical Microbiology, Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-5779-7386
Maria YazdanbakhshDepartment of Parasitology, Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-7666-1441
Mirjam H M HeemskerkDepartment of Hematology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0001-6320-9133
Hermelijn H SmitsDepartment of Parasitology, Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0001-9279-2890
Simon P JochemsDepartment of Parasitology, Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands. s.p.jochems@lumc.nl.ORCID http://orcid.org/0000-0002-4835-1032
in collaboration with BEAT-COVID group
in collaboration with COVID-19 LUMC group
Leiden University Medical Center · NLLeiden University · NL
Funding
Leids Universitair Medisch Centrum (Leiden University Medical Center) Gisela Thier FellowshipZonMw (Netherlands Organisation for Health Research and Development) 114025007
Abstract
Systemic immune cell dynamics during coronavirus disease 2019 (COVID-19) are extensively documented, but these are less well studied in the (upper) respiratory tract, where severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates
Indexed as
Antibodies, ViralCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCOVID-19GranulocytesHLA-DR AntigensHumansKiller Cells, NaturalMemory T CellsMonocytesNasopharynxNeutrophilsNoseProspective StudiesRespiratory MucosaSARS-CoV-2Antibodies, ViralHLA-DR Antigens
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT05560906ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.