ArticleNature chemical biology2022
Reaction pathway engineering converts a radical hydroxylase into a halogenase.
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Article in Nature chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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50citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
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Who cites it
50 citing papers in PubMed, 80 citations in OpenAlex.
- Experimental and Computational Elucidation of C(sp3)-H Fluorination Barriers in an Iron(II)- and 2-Oxoglutarate-Dependent Halogenase.Journal of the American Chemical Society · 2026Article
- HaloTag-Based FACS-Compatible Assay for Intracellular Haloalkane Detection with a Potential Application to Halogenase Screening.Analytical chemistry · 2026Article
- Influence of Primary Coordination Sphere on Anion Rebound Selectivity in Nonheme Fe Enzyme-Catalyzed C(sp3)-H Functionalization: A Comparative Experimental and Computational Study of EgtB and ACCO.Journal of the American Chemical Society · 2026Article
- Beyond Histone Demethylation: Mechanisms ofJACS Au · 2026Article
- Influence of Primary Coordination Sphere on Anion Rebound Selectivity in Nonheme Fe Enzyme-Catalyzed C(spbioRxiv : the preprint server for biology · 2026Article
- How Fe(II)/2-Oxoglutarate Oxygenase Chooses Chlorination over Hydroxylation: Electric Field-Driven Ligand Exchange Governs C-Cl Formation.Journal of the American Chemical Society · 2026Article
- Dynamic metal coordination controls chemoselectivity in a radical halogenase.Nature chemical biology · 2026Article
- Configurational isomerization around the metal center underlies chemoselectivity of a radical halogenase.Nature chemical biology · 2026Article
- Reprogramming Imine Reductases for Enantioselective Reduction of Electron-Rich Enamides.JACS Au · 2026Article
- A high-throughput biocatalytic platform for screening isomeric kainoid natural products.Cell reports. Physical science · 2026Article
- CURE-ating the Substrate Scope and Functional Residues of Nonheme Iron(II) α-Ketoglutarate-Dependent Hydroxylase BesE.Journal of natural products · 2026Article
- A High-Throughput Biocatalytic Platform for Screening Isomeric Kainoid Natural Products.bioRxiv : the preprint server for biology · 2025Article
- Approaches for regulating enzyme activities: Recent advances in experiment and computation.Current opinion in structural biology · 2025Review
- Directed Evolution of Nonheme Iron Enzymes for Enantioselective Aminative Difunctionalization of Alkenes.JACS Au · 2025Article
- Is a Malleable Active Site Loop the Key to High Substrate Promiscuity? Hybrid, Biocatalytic Route to Structurally Diverse Taxoid Side Chains with Remarkable Dual Stereocontrol.Angewandte Chemie (International ed. in English) · 2025Article
- Tracing the stepwise Darwinian evolution of a plant halogenase.Science advances · 2025Article
- Copper-Dependent Hydroxylation Catalyzed by the DUF3328 Enzyme CctR.Organic letters · 2025Article
- Cooperative Photometallobiocatalysis: Nonheme Fe Enzyme-Catalyzed Enantioconvergent Radical Decarboxylative Azidation, Thiocyanation, and Isocyanation of Redox-Active Esters.Angewandte Chemie (International ed. in English) · 2025Article
- Pangenome Analysis of the Plant Pathogen Pseudomonas syringae Reveals Unique Natural Products for Niche Adaptation.Angewandte Chemie (International ed. in English) · 2025Article
- Biochemical Studies of a Cyanobacterial Halogenase Support the Involvement of a Dimetal Cofactor.Biochemistry · 2025Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Monica E NeugebauerDepartment of Chemical & Biomolecular Engineering, University of California, Berkeley, Berkeley, CA, USA.
Elijah N KissmanDepartment of Chemistry, University of California, Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0002-3278-8010
Jorge A MarchandDepartment of Chemical & Biomolecular Engineering, University of California, Berkeley, Berkeley, CA, USA.
Jeffrey G PeltonQB3 Institute, University of California, Berkeley, Berkeley, CA, USA.
Nicholas A SamboldDepartment of Molecular & Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Douglas C MillarDepartment of Chemical & Biomolecular Engineering, University of California, Berkeley, Berkeley, CA, USA.
Michelle C Y ChangDepartment of Chemical & Biomolecular Engineering, University of California, Berkeley, Berkeley, CA, USA. mcchang@berkeley.edu.ORCID http://orcid.org/0000-0003-3747-7630
University of California, Berkeley · USBerkeley College · US
Funding
User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6MUniv of Calif Berkeley Chemistry-Biology Interface ProgramT32GM066698 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHANG, CHRISTOPHER J., FRANCIS, MATTHEW B · 2004 to 2023
$7.5MEliminating Critical Systematic Errors In Structural Biology With Next-Generation SimulationR01GM124149 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOLTON, JAMES M · 2017 to 2024
$2.5MDiscovery and Application of New HalogenasesR01GM134271 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHANG, MICHELLE C · 2020 to 2023
$1.5MHoward Hughes Medical InstituteNIGMS NIH HHS P30 GM124169NIGMS NIH HHS R01 GM124149NIGMS NIH HHS R01 GM134271NIGMS NIH HHS T32 GM066698
Abstract
Fe
Indexed as
Catalytic DomainHalogenationHalogensMixed Function OxygenasesModels, MolecularProtein ConformationProtein EngineeringSubstrate SpecificityHalogensMixed Function Oxygenases
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.