ArticleNeurology2022
Neuropathologic Correlates of Human Cortical Proteins in Alzheimer Disease and Related Dementias.
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Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
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15 citing papers in PubMed, 17 citations in OpenAlex.
- Proteomic dysregulation associated with cerebral amyloid angiopathy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
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- Association between Alzheimer's disease-related genes and neurodegenerative blood-based biomarkers in Indian adults.Frontiers in aging neuroscience · 2026Article
- Alzheimer Syndrome or Age-Related Dementia-History, Therapy and Prevention.Journal of clinical medicine · 2025Article
- DNA methylation as a contributor to dysregulation of STX6 and other frontotemporal Lobar degeneration genetic risk-associated loci.Acta neuropathologica communications · 2025Article
- DNA methylation as a contributor to dysregulation ofbioRxiv : the preprint server for biology · 2025Article
- Identification of novel candidate loci for Alzheimer's disease and related dementias by leveraging the shared genetic basis with hippocampal volume.Aging brain · 2025Article
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- Autophagy Markers Are Altered in Alzheimer's Disease, Dementia with Lewy Bodies and Frontotemporal Dementia.International journal of molecular sciences · 2024Article
- Controversial Past, Splendid Present, Unpredictable Future: A Brief Review of Alzheimer Disease History.Journal of clinical medicine · 2024Review
- Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob disease risk gene Stx6.Neurobiology of disease · 2024Article
- Moving beyond amyloid and tau to capture the biological heterogeneity of Alzheimer's disease.Trends in neurosciences · 2023Review
- Identification of highly reliable risk genes for Alzheimer's disease through joint-tissue integrative analysis.Frontiers in aging neuroscience · 2023Article
- A Pragmatic, Data-Driven Method to Determine Cutoffs for CSF Biomarkers of Alzheimer Disease Based on Validation Against PET Imaging.Neurology · 2022Article
- Open drug discovery in Alzheimer's disease.Alzheimer's & dementia (New York, N. Y.)Article
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Authors and funding
12 authors at 1 institution in 1 country.
Lei YuFrom the Rush Alzheimer's Disease Center (L.Y., P.A.B., J.Y., T.W., A.S.B., J.A.S., D.A.B.), Department of Neurological Sciences (L.Y., J.Y., T.W., A.S.B., D.A.B.), Department of Psychiatry and Behavioral Sciences (P.A.B.), and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL; Division of Mental Health (A.P.W.), Atlanta VA Medical Center, Decatur; Departments of Psychiatry (A.P.W.), Neurology (T.S.W., A.I.L.), and Human Genetics (T.S.W.), Emory University School of Medicine; Department of Biochemistry (N.T.S.), Emory University, Atlanta, GA; and Center for Translational and Computational Neuroimmunology (P.L.D.J.), Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain (P.L.D.J.), Columbia University Medical Center, New York, NY. lei_yu@rush.edu.
Patricia A BoyleFrom the Rush Alzheimer's Disease Center (L.Y., P.A.B., J.Y., T.W., A.S.B., J.A.S., D.A.B.), Department of Neurological Sciences (L.Y., J.Y., T.W., A.S.B., D.A.B.), Department of Psychiatry and Behavioral Sciences (P.A.B.), and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL; Division of Mental Health (A.P.W.), Atlanta VA Medical Center, Decatur; Departments of Psychiatry (A.P.W.), Neurology (T.S.W., A.I.L.), and Human Genetics (T.S.W.), Emory University School of Medicine; Department of Biochemistry (N.T.S.), Emory University, Atlanta, GA; and Center for Translational and Computational Neuroimmunology (P.L.D.J.), Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain (P.L.D.J.), Columbia University Medical Center, New York, NY.
Aliza P WingoFrom the Rush Alzheimer's Disease Center (L.Y., P.A.B., J.Y., T.W., A.S.B., J.A.S., D.A.B.), Department of Neurological Sciences (L.Y., J.Y., T.W., A.S.B., D.A.B.), Department of Psychiatry and Behavioral Sciences (P.A.B.), and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL; Division of Mental Health (A.P.W.), Atlanta VA Medical Center, Decatur; Departments of Psychiatry (A.P.W.), Neurology (T.S.W., A.I.L.), and Human Genetics (T.S.W.), Emory University School of Medicine; Department of Biochemistry (N.T.S.), Emory University, Atlanta, GA; and Center for Translational and Computational Neuroimmunology (P.L.D.J.), Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain (P.L.D.J.), Columbia University Medical Center, New York, NY.
Jingyun YangFrom the Rush Alzheimer's Disease Center (L.Y., P.A.B., J.Y., T.W., A.S.B., J.A.S., D.A.B.), Department of Neurological Sciences (L.Y., J.Y., T.W., A.S.B., D.A.B.), Department of Psychiatry and Behavioral Sciences (P.A.B.), and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL; Division of Mental Health (A.P.W.), Atlanta VA Medical Center, Decatur; Departments of Psychiatry (A.P.W.), Neurology (T.S.W., A.I.L.), and Human Genetics (T.S.W.), Emory University School of Medicine; Department of Biochemistry (N.T.S.), Emory University, Atlanta, GA; and Center for Translational and Computational Neuroimmunology (P.L.D.J.), Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain (P.L.D.J.), Columbia University Medical Center, New York, NY.
Tianhao WangFrom the Rush Alzheimer's Disease Center (L.Y., P.A.B., J.Y., T.W., A.S.B., J.A.S., D.A.B.), Department of Neurological Sciences (L.Y., J.Y., T.W., A.S.B., D.A.B.), Department of Psychiatry and Behavioral Sciences (P.A.B.), and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL; Division of Mental Health (A.P.W.), Atlanta VA Medical Center, Decatur; Departments of Psychiatry (A.P.W.), Neurology (T.S.W., A.I.L.), and Human Genetics (T.S.W.), Emory University School of Medicine; Department of Biochemistry (N.T.S.), Emory University, Atlanta, GA; and Center for Translational and Computational Neuroimmunology (P.L.D.J.), Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain (P.L.D.J.), Columbia University Medical Center, New York, NY.
Aron S BuchmanFrom the Rush Alzheimer's Disease Center (L.Y., P.A.B., J.Y., T.W., A.S.B., J.A.S., D.A.B.), Department of Neurological Sciences (L.Y., J.Y., T.W., A.S.B., D.A.B.), Department of Psychiatry and Behavioral Sciences (P.A.B.), and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL; Division of Mental Health (A.P.W.), Atlanta VA Medical Center, Decatur; Departments of Psychiatry (A.P.W.), Neurology (T.S.W., A.I.L.), and Human Genetics (T.S.W.), Emory University School of Medicine; Department of Biochemistry (N.T.S.), Emory University, Atlanta, GA; and Center for Translational and Computational Neuroimmunology (P.L.D.J.), Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain (P.L.D.J.), Columbia University Medical Center, New York, NY.
Thomas S WingoFrom the Rush Alzheimer's Disease Center (L.Y., P.A.B., J.Y., T.W., A.S.B., J.A.S., D.A.B.), Department of Neurological Sciences (L.Y., J.Y., T.W., A.S.B., D.A.B.), Department of Psychiatry and Behavioral Sciences (P.A.B.), and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL; Division of Mental Health (A.P.W.), Atlanta VA Medical Center, Decatur; Departments of Psychiatry (A.P.W.), Neurology (T.S.W., A.I.L.), and Human Genetics (T.S.W.), Emory University School of Medicine; Department of Biochemistry (N.T.S.), Emory University, Atlanta, GA; and Center for Translational and Computational Neuroimmunology (P.L.D.J.), Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain (P.L.D.J.), Columbia University Medical Center, New York, NY.ORCID 0000-0002-7679-6282
Nicholas T SeyfriedFrom the Rush Alzheimer's Disease Center (L.Y., P.A.B., J.Y., T.W., A.S.B., J.A.S., D.A.B.), Department of Neurological Sciences (L.Y., J.Y., T.W., A.S.B., D.A.B.), Department of Psychiatry and Behavioral Sciences (P.A.B.), and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL; Division of Mental Health (A.P.W.), Atlanta VA Medical Center, Decatur; Departments of Psychiatry (A.P.W.), Neurology (T.S.W., A.I.L.), and Human Genetics (T.S.W.), Emory University School of Medicine; Department of Biochemistry (N.T.S.), Emory University, Atlanta, GA; and Center for Translational and Computational Neuroimmunology (P.L.D.J.), Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain (P.L.D.J.), Columbia University Medical Center, New York, NY.ORCID 0000-0002-4507-624X
Allan I LeveyFrom the Rush Alzheimer's Disease Center (L.Y., P.A.B., J.Y., T.W., A.S.B., J.A.S., D.A.B.), Department of Neurological Sciences (L.Y., J.Y., T.W., A.S.B., D.A.B.), Department of Psychiatry and Behavioral Sciences (P.A.B.), and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL; Division of Mental Health (A.P.W.), Atlanta VA Medical Center, Decatur; Departments of Psychiatry (A.P.W.), Neurology (T.S.W., A.I.L.), and Human Genetics (T.S.W.), Emory University School of Medicine; Department of Biochemistry (N.T.S.), Emory University, Atlanta, GA; and Center for Translational and Computational Neuroimmunology (P.L.D.J.), Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain (P.L.D.J.), Columbia University Medical Center, New York, NY.
Philip L De JagerFrom the Rush Alzheimer's Disease Center (L.Y., P.A.B., J.Y., T.W., A.S.B., J.A.S., D.A.B.), Department of Neurological Sciences (L.Y., J.Y., T.W., A.S.B., D.A.B.), Department of Psychiatry and Behavioral Sciences (P.A.B.), and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL; Division of Mental Health (A.P.W.), Atlanta VA Medical Center, Decatur; Departments of Psychiatry (A.P.W.), Neurology (T.S.W., A.I.L.), and Human Genetics (T.S.W.), Emory University School of Medicine; Department of Biochemistry (N.T.S.), Emory University, Atlanta, GA; and Center for Translational and Computational Neuroimmunology (P.L.D.J.), Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain (P.L.D.J.), Columbia University Medical Center, New York, NY.ORCID 0000-0002-8057-2505
Julie A SchneiderFrom the Rush Alzheimer's Disease Center (L.Y., P.A.B., J.Y., T.W., A.S.B., J.A.S., D.A.B.), Department of Neurological Sciences (L.Y., J.Y., T.W., A.S.B., D.A.B.), Department of Psychiatry and Behavioral Sciences (P.A.B.), and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL; Division of Mental Health (A.P.W.), Atlanta VA Medical Center, Decatur; Departments of Psychiatry (A.P.W.), Neurology (T.S.W., A.I.L.), and Human Genetics (T.S.W.), Emory University School of Medicine; Department of Biochemistry (N.T.S.), Emory University, Atlanta, GA; and Center for Translational and Computational Neuroimmunology (P.L.D.J.), Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain (P.L.D.J.), Columbia University Medical Center, New York, NY.
David A BennettFrom the Rush Alzheimer's Disease Center (L.Y., P.A.B., J.Y., T.W., A.S.B., J.A.S., D.A.B.), Department of Neurological Sciences (L.Y., J.Y., T.W., A.S.B., D.A.B.), Department of Psychiatry and Behavioral Sciences (P.A.B.), and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL; Division of Mental Health (A.P.W.), Atlanta VA Medical Center, Decatur; Departments of Psychiatry (A.P.W.), Neurology (T.S.W., A.I.L.), and Human Genetics (T.S.W.), Emory University School of Medicine; Department of Biochemistry (N.T.S.), Emory University, Atlanta, GA; and Center for Translational and Computational Neuroimmunology (P.L.D.J.), Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain (P.L.D.J.), Columbia University Medical Center, New York, NY.
Rush University Medical Center · US
Funding
SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MRush Alzheimer's Disease Research CenterP30AG072975 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI Lisa L Barnes, Julie A. Schneider · 2021 to 2026
$24.7MRISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4MCharacterizing the Behavior Profile of Healthy Cognitive AgingR01AG034374 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI PATRICIA A BOYLE · 2009 to 2026
$8.8MUnderstanding the molecular mechanisms of Depression and Psychological Well-being in Alzheimer's diseaseR01AG056533 · NIA · EMORY UNIVERSITY · PI WINGO, ALIZA PHAM, WINGO, THOMAS SPURGEON · 2017 to 2021
$3.9MElucidating the Role of Plasma Cholesterol in Alzheimer's Disease using Mendelian RandomizationR56AG062633 · NIA · EMORY UNIVERSITY · PI WINGO, THOMAS SPURGEON · 2019 to 2019
$711kNIA NIH HHS P30 AG010161NIA NIH HHS P30 AG072975NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG034374NIA NIH HHS R01 AG056533NIA NIH HHS R56 AG062633
Abstract
BACKGROUND AND
objectivesAlzheimer dementia is a complex clinical syndrome that can be defined broadly as an amnestic multidomain dementia. We previously reported human cortical proteins that are implicated in Alzheimer dementia. To understand the pathologic correlates of these proteins for underlying disease mechanisms, we investigated cortical protein associations with common age-related neuropathologies.
methodsParticipants were community-dwelling older adults from 2 cohort studies of aging and dementia. All underwent detailed annual clinical evaluations, and brain autopsies were performed after death. We use Alzheimer disease (AD) to refer to pathologically defined disease and Alzheimer dementia to refer to the clinical syndrome. Indices for AD, cortical Lewy bodies, limbic predominant age-related TAR DNA binding protein
resultsA total of 391 older adults were included. We did not observe associations of these protein targets with pathologic diagnosis of AD. In contrast, multiple proteins were associated with non-AD neurodegenerative and cerebrovascular conditions. In particular, higher CHSP1 expression was associated with cortical Lewy bodies and macroscopic infarcts, and higher CATH expression was associated with LATE-NC and arteriolosclerosis. Furthermore, while higher STX6 expression increased the risk of Alzheimer dementia, the protein was not associated with any of the neuropathologic indices investigated. DISCUSSION: Cortical proteins implicated in Alzheimer dementia do not necessarily work through AD pathogenesis; rather, non-AD neurodegenerative and vascular diseases and other pathways are at play. Furthermore, some proteins are pleiotrophic and associated with both neurodegenerative and cerebrovascular pathologies.
Indexed as
Alzheimer DiseaseCerebral Amyloid AngiopathyNeurodegenerative DiseasesAgedbeta-LactamasesBrainHumansLewy BodiesMembrane ProteinsMitochondrial Proteinsbeta-LactamasesLACTB protein, humanMembrane ProteinsMitochondrial Proteins
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