Evidence map›Paper›PMID 34937266›Full record

ReviewIndian journal of ophthalmology2022

COVID-19-associated optic neuritis - A case series and review of literature.

Ajax Jossy, Ninan Jacob, Sandip Sarkar, Tanmay Gokhale, Subashini Kaliaperumal, Amit K Deb

Abstract readCase ReportsReview
In one paragraph

Review in Indian journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. Effects of coronavirus disease 2019 in patients with optic neuritis: a single-centre retrospective cohort study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  8. Clinical characteristics of optic neuritis following COVID-19 during Omicron outbreak in China.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Observational
  9. Article
  10. Review
  11. Article
  12. Article
  13. A review of neuro-ophthalmic sequelae following COVID-19 infection and vaccination.Frontiers in cellular and infection microbiology · 2024
    Review
  14. Article
  15. Article
  16. Review
  17. Neuro-Ophthalmic Complications of COVID-19 Infection and Vaccination.Advances in ophthalmology and optometry · 2023
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ajax JossyDepartment of Ophthalmology, Jawaharlal Institute Postgraduate Medical Education and Research, Puducherry, India.
Ninan JacobDepartment of Ophthalmology, Jawaharlal Institute Postgraduate Medical Education and Research, Puducherry, India.
Sandip SarkarDepartment of Ophthalmology, Jawaharlal Institute Postgraduate Medical Education and Research, Puducherry, India.
Tanmay GokhaleDepartment of Ophthalmology, Jawaharlal Institute Postgraduate Medical Education and Research, Puducherry, India.
Subashini KaliaperumalDepartment of Ophthalmology, Jawaharlal Institute Postgraduate Medical Education and Research, Puducherry, India.
Amit K DebDepartment of Ophthalmology, Jawaharlal Institute Postgraduate Medical Education and Research, Puducherry, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroophthalmic manifestations are very rare in corona virus disease-19 (COVID-19) infection. Only few reports have been published till date describing COVID-19-associated neuroophthalmic manifestations. We, hereby, present a series of three cases who developed optic neuritis during the recovery period from COVID-19 infection. Among the three patients, demyelinating lesions were identified in two cases, while another case was associated with serum antibodies against myelin oligodendrocyte glycoprotein. All three patients received intravenous methylprednisolone followed by oral steroids according to the Optic Neuritis Treatment Trail ptotocol. Vision recovery was noted in all three patients, which was maintained at 2 months of the last follow up visit.

Indexed as

COVID-19Optic NeuritisAutoantibodiesHumansMyelin-Oligodendrocyte GlycoproteinSARS-CoV-2AutoantibodiesMyelin-Oligodendrocyte GlycoproteinCOVID-19myelin oligodendrocyte glycoproteinneuroophthalmic manifestationoptic neuritis

Identifiers

PMID34937266
PMCPMC8917537

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.