ArticleMicrobiology spectrum2021
Enhanced Pathogenesis Caused by Influenza D Virus and Mycoplasma bovis Coinfection in Calves: a Disease Severity Linked with Overexpression of IFN-γ as a Key Player of the Enhanced Innate Immune Response in Lungs.
Article in Microbiology spectrum, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Molecular Characterisation, Isolation, and Antibody Response to Influenza D Virus in Naturally Infected Cattle.Viruses · 2026Article
- First Detection and Genetic Characterization of Influenza D Virus in Cattle in Spain.Veterinary sciences · 2026Article
- Genetic and Phylogenetic Characterization of Influenza D Viruses From South Korean Cattle, 2022-2023.Transboundary and emerging diseases · 2026Article
- Detection and Genomic Characterization of Novel Respiratory Viruses in US and Mexican Cattle Farms.Transboundary and emerging diseases · 2026Article
- Distinct influenza interfaces in cattle: repeated spillovers of highly pathogenic avian influenza A(H5N1) from wild birds and enzootic circulation of influenza D virus.Frontiers in cellular and infection microbiology · 2026Review
- Decoding the dynamics of calves' respiratory and gut microbiota: exploring stability, resistance, and individual patterns.Animal microbiome · 2025Article
- Influenza A Virus andInternational journal of molecular sciences · 2025Article
- Epidemiological Investigation and Phylogenetic Analysis of Bovine Respiratory Disease Complex in Northern China.Veterinary medicine and science · 2025Article
- T Cell Responses to Influenza Infections in Cattle.Viruses · 2025Review
- Host transcriptome response to Mycoplasma bovis and bovine viral diarrhea virus in bovine tissues.BMC genomics · 2025Article
- Plasma cytokine and chemokine levels during natural outbreaks of bovine respiratory disease in young bulls on feedlots.Frontiers in veterinary science · 2025Article
- Article
- Influenza D virus infection in China, 2022-2023.Emerging microbes & infections · 2024Article
- The forecasting power of the mucin-microbiome interplay in livestock respiratory diseases.The veterinary quarterly · 2024Article
- Article
- Proteomic and Lipidomic Profiling of Calves Experimentally Co-Infected with Influenza D Virus andViruses · 2024Article
- An injectable subunit vaccine containing Elongation Factor Tu and Heat Shock Protein 70 partially protects American bison fromFrontiers in veterinary science · 2024Article
- Prevalence and characterization of seven-segmented influenza viruses in bovine respiratory disease complex.Virology · 2023Article
- Detection of Influenza D-Specific Antibodies in Bulk Tank Milk from Swedish Dairy Farms.Viruses · 2023Article
- The Activation of the RIG-I/MDA5 Signaling Pathway upon Influenza D Virus Infection Impairs the Pulmonary Proinflammatory Response Triggered by Mycoplasma bovis Superinfection.Journal of virology · 2023Article
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bovine respiratory disease (BRD) is a major disease of young cattle whose etiology lies in complex interactions between pathogens and environmental and host factors. Despite a high frequency of codetection of respiratory pathogens in BRD, data on the molecular mechanisms and pathogenesis associated with viral and bacterial interactions are still limited. In this study, we investigated the effects of a coinfection with influenza D virus (IDV) and Mycoplasma bovis in cattle. Naive calves were infected by aerosol with a French IDV strain and an M. bovis strain. The combined infection shortened the incubation period, worsened the disease, and led to more severe macroscopic and microscopic lesions compared to these parameters in calves infected with only one pathogen. In addition, IDV promoted colonization of the lower respiratory tract (LRT) by M. bovis and increased white cell recruitment to the airway lumen. The transcriptomic analysis highlighted an upregulation of immune genes in the lungs of coinfected calves. The gamma interferon (IFN-γ) gene was shown to be the gene most statistically overexpressed after coinfection at 2 days postinfection (dpi) and at least until 7 dpi, which correlated with the high level of lymphocytes in the LRT. Downregulation of the PACE4 and TMPRSS2 endoprotease genes was also highlighted, being a possible reason for the faster clearance of IDV in the lungs of coinfected animals. Taken together, our coinfection model with two respiratory pathogens that when present alone induce moderate clinical signs of disease was shown to increase the severity of the disease in young cattle and a strong transcriptomic innate immune response in the LRT, especially for IFN-γ.
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