Evidence map›Paper›PMID 34937164›Full record

ArticleMicrobiology spectrum2021

EPSP Synthase-Depleted Cells Are Aromatic Amino Acid Auxotrophs in Mycobacterium smegmatis.

Mario Alejandro Duque-Villegas, Bruno Lopes Abbadi, Paulo Ricardo Romero, Letícia Beatriz Matter, Luiza Galina, Pedro Ferrari Dalberto, Valnês da Silva Rodrigues-Junior, Rodrigo Gay Ducati, Candida Deves Roth, Raoní Scheibler Rambo and 6 more

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Determination of Potential Inhibitors againstCurrent pharmaceutical design · 2026
    Review
  2. Identification of potential inhibitors againstJournal of enzyme inhibition and medicinal chemistry · 2024
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Mario Alejandro Duque-VillegasInstituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB), Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Partenon, Porto Alegre, Brazil.ORCID 0000-0002-1800-0450
Bruno Lopes AbbadiInstituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB), Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Partenon, Porto Alegre, Brazil.ORCID 0000-0002-4336-1282
Paulo Ricardo RomeroInstituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB), Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Partenon, Porto Alegre, Brazil.
Letícia Beatriz MatterInstituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB), Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Partenon, Porto Alegre, Brazil.
Luiza GalinaInstituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB), Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Partenon, Porto Alegre, Brazil.
Pedro Ferrari DalbertoInstituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB), Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Partenon, Porto Alegre, Brazil.
Valnês da Silva Rodrigues-JuniorInstituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB), Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Partenon, Porto Alegre, Brazil.ORCID 0000-0002-4849-2249
Rodrigo Gay DucatiInstituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB), Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Partenon, Porto Alegre, Brazil.
Candida Deves RothInstituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB), Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Partenon, Porto Alegre, Brazil.
Raoní Scheibler RamboInstituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB), Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Partenon, Porto Alegre, Brazil.
Eduardo Vieira de SouzaInstituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB), Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Partenon, Porto Alegre, Brazil.
Marcia Alberton PerelloInstituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB), Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Partenon, Porto Alegre, Brazil.
Héctor Ricardo MorbidoniLaboratorio de Microbiologia Molecular, Facultad de Ciencias Medicas, Universidad Nacional de Rosario, Rosario, Argentina.
Pablo MachadoInstituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB), Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Partenon, Porto Alegre, Brazil.
Luiz Augusto BassoInstituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB), Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Partenon, Porto Alegre, Brazil.
Cristiano Valim BizarroInstituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB), Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Partenon, Porto Alegre, Brazil.ORCID 0000-0002-2609-8996
Pontifícia Universidade Católica do Rio Grande do Sul · BRNational University of Rosario · ARUnivates · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The epidemiological importance of mycobacterial species is indisputable, and the necessity to find new molecules that can inhibit their growth is urgent. The shikimate pathway, required for the synthesis of important bacterial metabolites, represents a set of targets for inhibitors of Mycobacterium tuberculosis growth. The

Indexed as

3-Phosphoshikimate 1-CarboxyvinyltransferaseAmino Acid MotifsAmino Acids, AromaticAmino Acid SequenceBacterial ProteinsBiocatalysisKineticsMycobacterium smegmatisSequence Alignment3-Phosphoshikimate 1-CarboxyvinyltransferaseAmino Acids, AromaticBacterial ProteinschorismateCRISPRiessentialitygene silencingmolecular geneticsvulnerability

Identifiers

PMID34937164
PMCPMC8694188
OpenAlexW4200003273

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.