Evidence map›Paper›PMID 34937110›Full record

ArticleEuropean journal of dentistry2022

Utilizing the Potential of Antimicrobial Peptide LL-37 for Combating SARS-COV- 2 Viral Load in Saliva: an In Silico Analysis.

Nireeksha Nireeksha, Pavan Gollapalli, Sudhir Rama Varma, Mithra N Hegde, N Suchetha Kumari

Open access · hybridAbstract read
In one paragraph

Article in European journal of dentistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Nireeksha NireekshaDepartment of Conservative Dentistry and Endodontics, AB Shetty Memorial Institute of Dental Sciences, NITTE (deemed to be) University, Deralakatte, Mangaluru, Karnataka, India.ORCID 0000-0001-7056-1418
Pavan GollapalliCentral Research Laboratory, K.S. Hegde Medical Academy, NITTE (deemed to be) University, Deralakatte, Mangaluru, Karnataka, India.ORCID 0000-0002-7252-1564
Sudhir Rama VarmaDepartment of Clinical Sciences, Ajman University, Ajman, United Arab Emirates.ORCID 0000-0001-6793-9344
Mithra N HegdeDepartment of Conservative Dentistry and Endodontics, AB Shetty Memorial Institute of Dental Sciences, NITTE (deemed to be) University, Deralakatte, Mangaluru, Karnataka, India.ORCID 0000-0002-5618-6778
N Suchetha KumariDepartment of Biochemistry, K.S. Hegde Medical Academy, NITTE (deemed to be) University, Deralakatte, Mangaluru, Karnataka, India.ORCID 0000-0002-4571-8716
K S Hegde Medical Academy · INNitte University · INAjman University · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Limiting the spread of virus during the recent pandemic outbreak was a major challenge. Viral loads in saliva, nasopharyngeal and oropharyngeal swabs were the major cause for droplet transmission and aerosols. Saliva being the major contributor for the presence of viral load is the major key factor; various mouthwashes and their combination were analyzed and utilized in health care centers to hamper the spread of virus and decrease viral load. The compositions of these mouthwashes to an extent affected the viral load and thereby transmission, but there is always a scope for other protocols which may provide better results. Here we evaluated the potential of antimicrobial peptide LL-37 in decreasing the viral load of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through an

Identifiers

PMID34937110
PMCPMC9507610
OpenAlexW4200201610

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.