Evidence map›Paper›PMID 34937053›Full record

ArticleNature2022

Morphogen gradient scaling by recycling of intracellular Dpp.

Maria Romanova-Michaelides, Zena Hadjivasiliou, Daniel Aguilar-Hidalgo, Dimitris Basagiannis, Carole Seum, Marine Dubois, Frank Jülicher, Marcos Gonzalez-Gaitan

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
5.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
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  5. Article
  6. Position-dependent feedback drives scaling and robustness of morphogen gradients.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
  8. Linking tissue morphology and tissue healing in a cell-fate model.Frontiers in cell and developmental biology · 2026
    Article
  9. Static morphogen scaling enables proportional growth in a tissue growth model inspired by axolotl limb regeneration.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Morphogens in the evolution of size, shape and patterning.Development (Cambridge, England) · 2024
    Review
  18. Diffusion barriers imposed by tissue topology shape Hedgehog morphogen gradients.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  19. Article
  20. Precise and scalable self-organization in mammalian pseudo-embryos.Nature structural & molecular biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Maria Romanova-Michaelides *Department of Biochemistry, Faculty of Sciences, University of Geneva, Geneva, Switzerland. maria.romanova@unige.ch.
Zena Hadjivasiliou *Department of Biochemistry, Faculty of Sciences, University of Geneva, Geneva, Switzerland.
Daniel Aguilar-HidalgoDepartment of Biochemistry, Faculty of Sciences, University of Geneva, Geneva, Switzerland.
Dimitris BasagiannisDepartment of Biochemistry, Faculty of Sciences, University of Geneva, Geneva, Switzerland.
Carole SeumDepartment of Biochemistry, Faculty of Sciences, University of Geneva, Geneva, Switzerland.
Marine DuboisDepartment of Biochemistry, Faculty of Sciences, University of Geneva, Geneva, Switzerland.
Frank JülicherMax Planck Institute for the Physics of Complex Systems, Dresden, Germany. julicher@pks.mpg.de.ORCID http://orcid.org/0000-0003-4731-9185
Marcos Gonzalez-GaitanDepartment of Biochemistry, Faculty of Sciences, University of Geneva, Geneva, Switzerland. marcos.gonzalez@unige.ch.ORCID http://orcid.org/0000-0002-6295-7321
University of Geneva · CHMax Planck Institute for the Physics of Complex Systems · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Morphogen gradients are fundamental to establish morphological patterns in developing tissues

Indexed as

Drosophila melanogasterDrosophila ProteinsEndocytosisMorphogenesisAnimalsWings, Animaldpp protein, DrosophilaDrosophila Proteins

Identifiers

PMID34937053
OpenAlexW4200432194

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.