ArticleNature2022
Local and systemic responses to SARS-CoV-2 infection in children and adults.
Open access · hybridAbstract readComparative Study
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 230 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
230citing papers in PubMed, 2 pooled it
16.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
230 citing papers in PubMed, 2 syntheses or guidelines pooled it, 343 citations in OpenAlex.
- Mucosal immune response in biology, disease prevention and treatment.Signal transduction and targeted therapy · 2025Pooled it
- Vaccination against influenza viruses reduces infection, not hospitalization or death, from respiratory COVID-19: A systematic review and meta-analysis.Journal of medical virology · 2024Pooled it
- Circulating hematopoietic stem/progenitor cell subsets contribute to human hematopoietic homeostasis.Blood · 2024Trial
- Signs of Cross-Reactivity Between SARS-CoV-2 and Other Coronaviruses in a Pre-Vaccine Swedish School Setting.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Nasal Epithelial Immune Signatures Are Associated With Age-Dependent Asthma Trajectories in Early Life.Allergy · 2026Observational
- Truncating RELA variants drive autoinflammation and autoimmunity by impairing the negative feedback control of NF-κB.JCI insight · 2026Article
- scDiagnostics: systematic assessment of cell type annotation in single-cell transcriptomics data.Briefings in bioinformatics · 2026Article
- CD38-activated macrophages drive age-related placental senescence by depleting NADNature communications · 2026Article
- Senescence and Hypoxia Regulate Colon Cancer Cell Transcriptome and Secretome: Insights into Cancer Cell Senescence Pathophysiology.Biomolecules · 2026Article
- Review
- Ageing-associated regenerative failure in the lung: stem cell senescence and transitional cell persistence in idiopathic pulmonary fibrosis.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Article
- Observational
- Hierarchical classification of immune cell transcriptomes at population-scale.bioRxiv : the preprint server for biology · 2026Article
- Lung mucosal and systemic responses at single-cell resolution in an aerosolized Mycobacterium bovis BCG human challenge model.Cell reports. Medicine · 2026Article
- Single-cell profiling reveals CCL5Hi GZMAHi effector memory CD8 T cell association to oligoarticular JIA.Rheumatology (Oxford, England) · 2026Article
- Upper and Lower Respiratory Tract Compartmentalization in Pediatric Stem Cell Transplantation.American journal of respiratory cell and molecular biology · 2026Article
- Prevalence, associated factors and treatment prescriptions for community-acquired pneumonia: a cross-sectional study at the largest children's hospital in the Ashanti Region, Ghana.BMC infectious diseases · 2026Article
- Immune-metabolic trajectories delineate subgroups in paediatric long COVID.Nature communications · 2026Article
- scHILL: deciphering individual-level immune cell heterogeneity with single-cell RNA sequencing data.Briefings in bioinformatics · 2026Article
170 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
57 authors at 12 institutions in 3 countries.
Masahiro Yoshida *UCL Respiratory, Division of Medicine, University College London, London, UK.ORCID http://orcid.org/0000-0002-3521-5322
Kaylee B Worlock *UCL Respiratory, Division of Medicine, University College London, London, UK.ORCID http://orcid.org/0000-0002-5656-7634
Ni Huang *Wellcome Sanger Institute, Cambridge, UK.
Rik G H Lindeboom *Wellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-3660-504X
Colin R ButlerNIHR Great Ormond Street BRC and UCL Institute of Child Health, London, UK.
Natsuhiko KumasakaWellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-3557-0375
Cecilia Dominguez CondeWellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-8684-4655
Lira MamanovaWellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0003-1463-8622
Liam BoltWellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0001-7293-0774
Laura RichardsonWellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-8075-3816
Krzysztof PolanskiWellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-2586-9576
Elo MadissoonWellcome Sanger Institute, Cambridge, UK.
Josephine L BarnesUCL Respiratory, Division of Medicine, University College London, London, UK.ORCID http://orcid.org/0000-0001-9938-3176
Jessica Allen-HyttinenUCL Respiratory, Division of Medicine, University College London, London, UK.ORCID http://orcid.org/0000-0003-4644-0362
Eliz KilichUniversity College London Hospitals NHS Foundation Trust, London, UK.
Brendan C JonesNIHR Great Ormond Street BRC and UCL Institute of Child Health, London, UK.ORCID http://orcid.org/0000-0002-2637-8859
Angus de WiltonUniversity College London Hospitals NHS Foundation Trust, London, UK.
Anna Wilbrey-ClarkWellcome Sanger Institute, Cambridge, UK.
Waradon SungnakWellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-0136-4960
J Patrick PettWellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-5249-444X
Juliane WellerWellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-1310-6168
Elena PrigmoreWellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0001-8870-0316
Henry YungUCL Respiratory, Division of Medicine, University College London, London, UK.
Puja MehtaUCL Respiratory, Division of Medicine, University College London, London, UK.
Aarash SalehRoyal Free Hospital NHS Foundation Trust, London, UK.
Anita SaigalRoyal Free Hospital NHS Foundation Trust, London, UK.
Vivian ChuRoyal Free Hospital NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0003-1376-1186
Jonathan M CohenUniversity College London Hospitals NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0003-1004-5598
Clare CaneRoyal Free Hospital NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0002-3545-768X
Aikaterini IordanidouRoyal Free Hospital NHS Foundation Trust, London, UK.
Soichi ShibuyaNIHR Great Ormond Street BRC and UCL Institute of Child Health, London, UK.ORCID http://orcid.org/0000-0002-4274-1312
Ann-Kathrin ReuschlUCL Division of Infection and Immunity, University College London, London, UK.
Iván T HerczegUCL Respiratory, Division of Medicine, University College London, London, UK.ORCID http://orcid.org/0000-0003-1281-3634
A Christine ArgentoDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Richard G WunderinkDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-8527-4195
Sean B SmithDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Taylor A PoorDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Catherine A GaoDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-5576-3943
Jane E DematteDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
NU SCRIPT Study Investigators
Gary ReynoldsBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID http://orcid.org/0000-0002-8142-8708
Muzlifah HaniffaWellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-3927-2084
Georgina S BowyerDepartment of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-2058-4045
Matthew CoatesDepartment of Medicine, University of Cambridge, Cambridge, UK.
Menna R ClatworthyWellcome Sanger Institute, Cambridge, UK.
Fernando J Calero-NietoWellcome, MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-3358-8253
Berthold GöttgensWellcome, MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-6302-5705
Christopher O'CallaghanNIHR Great Ormond Street BRC and UCL Institute of Child Health, London, UK.
Neil J SebireNIHR Great Ormond Street BRC and UCL Institute of Child Health, London, UK.
Clare JollyUCL Division of Infection and Immunity, University College London, London, UK.ORCID http://orcid.org/0000-0002-4603-2281
Paolo De CoppiNIHR Great Ormond Street BRC and UCL Institute of Child Health, London, UK.ORCID http://orcid.org/0000-0002-1659-0207
Claire M SmithNIHR Great Ormond Street BRC and UCL Institute of Child Health, London, UK.ORCID http://orcid.org/0000-0002-8913-0009
Alexander V MisharinDivision of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-2879-3789
Sam M JanesUCL Respiratory, Division of Medicine, University College London, London, UK.ORCID http://orcid.org/0000-0002-6634-5939
Sarah A TeichmannWellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-6294-6366
Marko Z NikolićUCL Respiratory, Division of Medicine, University College London, London, UK. m.nikolic@ucl.ac.uk.ORCID http://orcid.org/0000-0001-6304-6848
Kerstin B MeyerWellcome Sanger Institute, Cambridge, UK. km16@sanger.ac.uk.ORCID http://orcid.org/0000-0001-5906-1498
Wellcome Sanger Institute · GBNorthwestern University · USUniversity College London Hospitals NHS Foundation Trust · GBUniversity College London · GBGreat Ormond Street Hospital · GBRoyal Free London NHS Foundation Trust · GBUniversity of Cambridge · GBWellcome/MRC Cambridge Stem Cell Institute · GBGreat Ormond Street Hospital for Children NHS Foundation Trust · GBEuropean Bioinformatics Institute · GBJikei University School of Medicine · JPNewcastle University · GB
Funding
Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8MTissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GR Scott Budinger · 2015 to 2026
$26.9MTechnology CoreU19AI135964 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LUIS A. Nunes AMARAL · 2018 to 2026
$24.7MThe Cell Phenotyping and Mouse CoreP01HL154998 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE · 2021 to 2026
$18.9MTraining Program In Lung SciencesT32HL076139 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE, Jacob I Sznajder · 2004 to 2026
$9.6MMechanisms of regulatory T cell-mediated recovery from severe viral pneumoniaR01HL149883 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Benjamin David Singer · 2020 to 2026
$4.1MLung transplant injury drives chronic lung allograft dysfunction via recruitment ofmonocyte-derived alveolar macrophagesR01HL153312 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MISHARIN, ALEXANDER · 2020 to 2023
$2.9MEpigenetic modifiers of regulatory T cell function following viral pneumoniaR01HL153122 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SINGER, BENJAMIN DAVID · 2021 to 2021
$63kMedical Research Council MC_PC_17230Medical Research Council MC_PC_20022Medical Research Council MR/K017047/1Medical Research Council MR/R015635/1Medical Research Council MR/S005579/1Medical Research Council MR/S035842/1Medical Research Council MR/S036113/1Medical Research Council MR/W014556/1NCATS NIH HHS UL1 TR001422NHLBI NIH HHS P01 HL154998NHLBI NIH HHS R01 HL149883NHLBI NIH HHS R01 HL153122NHLBI NIH HHS R01 HL153312NHLBI NIH HHS T32 HL076139NIAID NIH HHS U19 AI135964NIA NIH HHS P01 AG049665Wellcome Trust 223065Wellcome Trust WT211276/Z/18/Z
Abstract
It is not fully understood why COVID-19 is typically milder in children
Indexed as
AdultBronchiChicagoCohort StudiesCOVID-19Dendritic CellsDisease ProgressionEpithelial CellsFemaleHumansImmunity, InnateInterferonsKiller Cells, NaturalLondonMaleNasal MucosaInterferons
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.