ArticleJournal of neural engineering2022
Transcranial photoacoustic characterization of neurovascular physiology during early-stage photothrombotic stroke in neonatal piglets
Article in Journal of neural engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Optoacoustic brain imaging: A systematic review and field mapping.Photoacoustics · 2026Article
- Multiscale photoacoustic imaging of stroke in preclinical models and future directions toward clinical translation [Invited].Biomedical optics express · 2026Review
- Automatic photoacoustic monitoring of perinatal brain hypoxia with superior sagittal sinus detection.Journal of biomedical optics · 2025Article
- Review
- Non-Invasive Photoacoustic Cerebrovascular Monitoring of Early-Stage Ischemic Strokes In Vivo.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Ultrasound-assisted aberration correction of transcranial photoacoustic imaging based on angular spectrum theory.Photoacoustics · 2024Article
- Multiparametric Brain Hemodynamics Imaging Using a Combined Ultrafast Ultrasound and Photoacoustic System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Evaluation of ultrasound sensors for transcranial photoacoustic sensing and imaging.Photoacoustics · 2023Article
- Development and characterization of transfontanelle photoacoustic imaging system for detection of intracranial hemorrhages and measurement of brain oxygenation:Photoacoustics · 2023Article
- High-contrast spectroscopic photoacoustic characterization of thermal tissue ablation in the visible spectrum.Ultrasonography (Seoul, Korea) · 2023Article
- Synthetic radial aperture focusing to regulate manual volumetric scanning for economic transrectal ultrasound imaging.Ultrasonics · 2023Article
- Animal models of focal ischemic stroke: brain size matters.Frontiers in stroke · 2023Review
- Photoacoustic assessment of the fetal brain and placenta as a method of non-invasive antepartum and intrapartum monitoring.Experimental neurology · 2022Review
- Sound out the impaired perfusion: Photoacoustic imaging in preclinical ischemic stroke.Frontiers in neuroscience · 2022Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectivePerinatal ischemic stroke is estimated to occur in 1/2300-1/5000 live births, but early differential diagnosis from global hypoxia-ischemia is often difficult. In this study, we tested the ability of a hand-held transcranial photoacoustic (PA) imaging probe to non-invasively detect a focal photothrombotic stroke (PTS) within 2 h of stroke onset in a gyrencephalic piglet brain. APPROACH: About 17 stroke lesions of approximately 1 cm MAIN
resultsThe PA-derived tissue oxygen saturation at 2 h yielded a significant separation between control and affected regions-of-interest ( SIGNIFICANCE: This study shows that a hand-held transcranial PA neuroimaging device can detect a regional thrombotic stroke in the cerebral cortex of a neonatal piglet. In particular, we conclude that the oxygen saturation metric can be used alone to identify regional stroke lesions. The lack of change in tHb may be related to arbitrary hand-held imaging configuration and/or entrapment of red blood cells within the thrombotic stroke.
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Registered trials
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