ArticleJournal of affective disorders2022
White matter microstructure associated with anhedonia among individuals with bipolar disorders and high-risk for bipolar disorders.
Article in Journal of affective disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Distress, burden, and wellbeing in siblings of people with mental illness: a mixed studies systematic review and meta-analysis.Psychological medicine · 2023Pooled it
- Altered white matter integrity in pediatric bipolar disorder and the potential role of psychotic symptoms revealed by free water elimination corrected and superficial white matter DTI analyses.European child & adolescent psychiatry · 2026Article
- The neurobiology of motivational anhedonia in patients with depression.Brain imaging and behavior · 2025Article
- Sex differences in anhedonia in bipolar depression: a resting-state fMRI study.European archives of psychiatry and clinical neuroscience · 2025Article
- Anhedonia is associated with a specific depression profile and poor antidepressant response.The international journal of neuropsychopharmacology · 2024Article
- Psychometric properties of the Clinical Assessment Interview for Negative Symptoms (CAINS) in patients with depression and its relationship to affective symptoms.Annals of general psychiatry · 2023Article
- Segmental abnormalities of superior longitudinal fasciculus microstructure in patients with schizophrenia, bipolar disorder, and attention-deficit/hyperactivity disorder: An automated fiber quantification tractography study.Frontiers in psychiatry · 2022Article
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Authors and funding
12 authors at 2 institutions in 2 countries.
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Abstract
backgroundAnhedonia - a key symptom of depression - is highly associated with poorer outcomes and suicidal behavior. Alterations in the circuitry of reward-related brain regions have been robustly associated with anhedonia in unipolar depression, but not bipolar disorder (BD). We investigated white matter microstructures associated with anhedonia in participants with BD types I and II and first-degree relatives of patients with BD (BD-siblings).
methodsEighty participants (BD types I and II: 56 [70%], and BD-siblings: 24 [30%]) underwent diffusion tensor imaging (DTI); Fractional anisotropy (FA) of different tracts were computed. Anhedonia was assessed using item 8, ("inability to feel'') of the MADRS scale. General linear models were used to compare the FA of different tracts in participants with and without anhedonia controlling for several clinical and demographic variables.
resultsThe mean age of the sample was 37 (± 11) years old, and 68.8% were female. Participants with anhedonia (32.5%) presented lower mean FA in the left uncinate fasciculus (UF) (p = 0.005), right temporal endings of the superior longitudinal fasciculus (SLFT) (p = 0.04), and in the left and right parietal endings of the superior longitudinal fasciculus (SLFP) (p = 0.003, and p = 0.04, respectively). Similar comparisons between participants with or without current depressive episodes and between participants with or without inner tension according to the MADRS did not show significant differences, specificity of the findings for anhedonia.
conclusionsLower FA in the left UF and SLF are potential neuroimaging markers of anhedonia in individuals with BD and high-risk for BD.
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