ArticleCell reports2021
Stepwise disassembly of GABAergic synapses during pathogenic excitotoxicity.
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Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
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Who cites it
25 citing papers in PubMed, 35 citations in OpenAlex.
- Loberamisal injection for the treatment of acute ischaemic stroke: a multicentre, randomised, double-blind, placebo-controlled phase II clinical trial.Stroke and vascular neurology · 2026Trial
- Loberamisal for Acute Ischaemic Stroke (LAIS): a multicentre, randomised, double-blind, parallel, placebo-controlled phase III clinical trial.Stroke and vascular neurology · 2026Trial
- Neuroligins and Neuropathic Pain: Insights into Synaptic Plasticity and Pain Transmission.Biology · 2026Review
- Distinct nanoscale architectures of GABAergic inhibitory synapses predict diverse synaptic output.bioRxiv : the preprint server for biology · 2026Article
- Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage.Molecular psychiatry · 2026Article
- Alzheimer's genetic risk factor Bin1 controls synapse vesicle exo-endocytosis in inhibitory synapses.Cell reports · 2025Article
- GABA and astrocytic cholesterol determine the lipid environment of GABACommunications biology · 2025Article
- Release your inhibitions: The cell biology of GABAergic postsynaptic plasticity.Current opinion in neurobiology · 2025Review
- Chronic benzodiazepine treatment triggers gephyrin scaffold destabilization and GABAFrontiers in cellular neuroscience · 2025Article
- Super-resolution imaging of the neuronal cytoskeleton.Npj imaging · 2024Review
- Disrupting stroke-induced GAT-1-syntaxin1A interaction promotes functional recovery after stroke.Cell reports. Medicine · 2024Article
- Reperfusion and cytoprotective agents are a mutually beneficial pair in ischaemic stroke therapy: an overview of pathophysiology, pharmacological targets and candidate drugs focusing on excitotoxicity and free radical.Stroke and vascular neurology · 2024Review
- TRPM2 and CaMKII Signaling Drives Excessive GABAergic Synaptic Inhibition Following Ischemia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Astroglial CD38 impairs hippocampal synaptic plasticity after global cerebral ischemia.Frontiers in stroke · 2024Article
- Preclinical evaluation of ZL006-05, a new antistroke drug with fast-onset antidepressant and anxiolytic effects.Stroke and vascular neurology · 2023Article
- Article
- nNOS and Neurological, Neuropsychiatric Disorders: A 20-Year Story.Neuroscience bulletin · 2023Review
- Inhibitory Synaptic Influences on Developmental Motor Disorders.International journal of molecular sciences · 2023Review
- Regulation of cargo exocytosis by a Reps1-Ralbp1-RalA module.Science advances · 2023Article
- The CaNeuropharmacology · 2022Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Joshua D GarciaDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045, USA.
Sara E GookinDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045, USA.
Kevin C CrosbyDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045, USA.
Samantha L SchwartzDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045, USA.
Erika TiemeierDepartment of Anesthesiology, Neuronal Injury Program, University of Colorado School of Medicine, Anschutz Medical Campus, 12801 East 17th Avenue, Aurora, CO 80045, USA.
Matthew J KennedyDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045, USA.
Mark L Dell'AcquaDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045, USA.
Paco S HersonDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045, USA; Department of Anesthesiology, Neuronal Injury Program, University of Colorado School of Medicine, Anschutz Medical Campus, 12801 East 17th Avenue, Aurora, CO 80045, USA.
Nidia QuillinanDepartment of Anesthesiology, Neuronal Injury Program, University of Colorado School of Medicine, Anschutz Medical Campus, 12801 East 17th Avenue, Aurora, CO 80045, USA.
Katharine R SmithDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045, USA. Electronic address: katharine.r.smith@cuanschutz.edu.
University of Colorado Anschutz Medical Campus · US
Funding
University of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LORI SUSSEL · 2020 to 2026
$10.8MZEBRAFISH TRANSGENIC CORE - ROCKY MOUNTAIN NEUROLOGICAL DISORDERS CORE CENTERP30NS048154 · NINDS · UNIVERSITY OF COLORADO DENVER · PI RIBERA, ANGELES BADELL · 2004 to 2020
$10.1MRegulation of Calcium-permeable AMPA Receptors by AKAP79 Postsynaptic SignalingR01NS040701 · NINDS · UNIVERSITY OF COLORADO DENVER · PI DELL'ACQUA, MARK L · 2001 to 2023
$7.7MSex Steroids and Brain Outcome from Cardiac Arrest/Cardiopulmonary ResuscitationR01NS046072 · NINDS · UNIVERSITY OF COLORADO DENVER · PI HERSON, PACO S, QUILLINAN, NIDIA · 2002 to 2024
$7.0MPREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM007635 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI DELL'ACQUA, MARK L · 1985 to 2023
$6.1MNovel approaches for interrogating and manipulating synaptic function, structure and plasticityR35NS116879 · NINDS · UNIVERSITY OF COLORADO DENVER · PI Matthew J Kennedy · 2020 to 2026
$4.0ML-type Ca2+ Channel Spike Regulation of Spine Structural Plasticity and Excitation-Transcription CouplingR01MH123700 · NIMH · UNIVERSITY OF COLORADO DENVER · PI DELL'ACQUA, MARK L · 2021 to 2025
$2.8MNanoscale organization of the inhibitory synapse during synaptic plasticityR01MH119154 · NIMH · UNIVERSITY OF COLORADO DENVER · PI SMITH, KATHARINE RACHEL · 2020 to 2024
$2.0MTargeting TRPM2 channels to improve synaptic and cognitive function after cerebral ischemiaR01NS092645 · NINDS · UNIVERSITY OF COLORADO DENVER · PI HERSON, PACO S · 2016 to 2020
$1.7MThe role of dendritic excitatibility in controlling GABAergic synapse maturationK00MH134674 · NIMH · UNIVERSITY OF COLORADO DENVER · PI Joshua Daylon Garcia · 2023 to 2026
$324kAn optogenetic tool for acute modulation of inhibitory synaptic functionF32MH123053 · NIMH · UNIVERSITY OF COLORADO DENVER · PI OLAH, SAMANTHA · 2020 to 2023
$216kUnderstanding the temporal regulation of inhibitory synapse depression and elimination in the context of cerebral ischemiaF99NS120640 · NINDS · UNIVERSITY OF COLORADO DENVER · PI GARCIA, JOSHUA DAYLON · 2021 to 2022
$72kAmerican Heart Association-American Stroke Association 19PRE34380542NIDDK NIH HHS P30 DK116073NIGMS NIH HHS T32 GM007635NIMH NIH HHS F32 MH123053NIMH NIH HHS K00 MH134674NIMH NIH HHS R01 MH119154NIMH NIH HHS R01 MH123700NINDS NIH HHS F99 NS120640NINDS NIH HHS P30 NS048154NINDS NIH HHS R01 NS040701NINDS NIH HHS R01 NS046072NINDS NIH HHS R01 NS092645NINDS NIH HHS R35 NS116879
Abstract
GABAergic synaptic inhibition controls neuronal firing, excitability, and synaptic plasticity to regulate neuronal circuits. Following an acute excitotoxic insult, inhibitory synapses are eliminated, reducing synaptic inhibition, elevating circuit excitability, and contributing to the pathophysiology of brain injuries. However, mechanisms that drive inhibitory synapse disassembly and elimination are undefined. We find that inhibitory synapses are disassembled in a sequential manner following excitotoxicity: GABA
Indexed as
AnimalsBrain InjuriesFemaleMaleMembrane ProteinsMiceMice, Inbred C57BLNeuronal PlasticityNeuronsPresynaptic TerminalsRatsRats, Sprague-DawleyReceptors, GABA-ASignal TransductionSynapsescalpain activatorgephyrinMembrane ProteinsReceptors, GABA-AcalcineurincalpaindSTORMGABA(A) receptorgephyrininhibitory synapseischemiaOGDSIMsuper-resolution microscopy
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.