Evidence map›Paper›PMID 34936832›Full record

ArticleApplied and environmental microbiology2022

Intradermally Administered Enterotoxigenic Escherichia coli Vaccine Candidate MecVax Induces Functional Serum Immunoglobulin G Antibodies against Seven Adhesins (CFA/I and CS1 through CS6) and Both Toxins (STa and LT).

Carolina Y Garcia, Hyesuk Seo, David A Sack, Weiping Zhang

Open access · greenAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Recent progress in enterotoxigenicInfection and immunity · 2025
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Evaluation of Multivalent EnterotoxigenicApplied and environmental microbiology · 2022
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Carolina Y GarciaKansas State Universitygrid.36567.31, Department of Diagnostic Medicine/Pathobiology, Manhattan, Kansas, USA.
Hyesuk SeoKansas State Universitygrid.36567.31, Department of Diagnostic Medicine/Pathobiology, Manhattan, Kansas, USA.
David A SackJohns Hopkins Universitygrid.21107.35 Bloomberg School of Public Health, Department of International Health, Baltimore, Maryland, USA.ORCID 0000-0002-9338-5119
Weiping ZhangKansas State Universitygrid.36567.31, Department of Diagnostic Medicine/Pathobiology, Manhattan, Kansas, USA.ORCID 0000-0002-3723-2257
University of Illinois Urbana-Champaign · USJohns Hopkins University · USKansas State University · US

Funding

A broadly protective subunit vaccine against enterotoxigenic Escherichia coli (ETEC) associateddiarrheaR01AI121067 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI ZHANG, WEIPING · 2016 to 2020
$2.0M
NIAID NIH HHS R01 AI121067
6 · The paper itself

Abstract

There are no vaccines licensed for enterotoxigenic Escherichia coli (ETEC), a leading bacterial cause of children's diarrhea and travelers' diarrhea. MecVax, a multivalent E. coli vaccine candidate composed of two epitope- and structure-based polyvalent proteins (toxoid fusion 3xSTa

Indexed as

Bacterial ToxinsEnterotoxigenic Escherichia coliEscherichia coli InfectionsEscherichia coli ProteinsEscherichia coli VaccinesAnimalsAntibodies, BacterialAntigens, BacterialDiarrheaEnterotoxinsFibrinogenImmunoglobulin GMiceAntibodies, BacterialAntigens, BacterialBacterial ToxinsEnterotoxinsEscherichia coli ProteinsEscherichia coli VaccinesFibrinogenImmunoglobulin Gdiarrheaenterotoxigenic Escherichia coliETECintradermal routeMecVaxvaccine

Identifiers

PMID34936832
PMCPMC8863059
OpenAlexW4200086690

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.