Evidence map›Paper›PMID 34936710›Full record

ArticleCell proliferation2022

Human mesenchymal stem cells.

Xiaoyong Chen, Jing Huang, Jun Wu, Jie Hao, Boqiang Fu, Ying Wang, Bo Zhou, Tao Na, Jun Wei, Yong Zhang and 14 more

Abstract read
In one paragraph

Article in Cell proliferation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
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  14. Ex vivo-generated human CD1cMolecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
  15. Review
  16. Article
  17. Endothelial Reprogramming in Atherosclerosis.Bioengineering (Basel, Switzerland) · 2024
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Xiaoyong ChenCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, China.
Jing HuangCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, China.
Jun WuChinese Society for Stem Cell Research, Shanghai, China.
Jie HaoChinese Society for Stem Cell Research, Shanghai, China.ORCID https://orcid.org/0000-0002-7739-1850
Boqiang FuChinese Society for Stem Cell Research, Shanghai, China.
Ying WangShanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China.
Bo ZhouChinese Society for Stem Cell Research, Shanghai, China.
Tao NaNational Institutes for Food and Drug Control, Beijing, China.
Jun WeiChinese Society for Stem Cell Research, Shanghai, China.
Yong ZhangChinese Society for Stem Cell Research, Shanghai, China.
Qiyuan LiChinese Society for Stem Cell Research, Shanghai, China.
Shijun HuChinese Society for Stem Cell Research, Shanghai, China.ORCID https://orcid.org/0000-0002-0068-8429
Jiaxi ZhouChinese Society for Stem Cell Research, Shanghai, China.
Junying YuChinese Society for Stem Cell Research, Shanghai, China.
Zhaohui WuChina Medicinal Biotech Association, Beijing, China.
Huanxin ZhuChinese Society for Stem Cell Research, Shanghai, China.
Jiani CaoChinese Society for Stem Cell Research, Shanghai, China.
Lei WangChinese Society for Stem Cell Research, Shanghai, China.
Yaojin PengChinese Society for Stem Cell Research, Shanghai, China.ORCID https://orcid.org/0000-0002-3909-6041
Lingmin LiangChinese Society for Stem Cell Research, Shanghai, China.
Aijin MaChinese Society for Stem Cell Research, Shanghai, China.
Yu ZhangChinese Society for Stem Cell Research, Shanghai, China.
Tongbiao ZhaoChinese Society for Stem Cell Research, Shanghai, China.ORCID https://orcid.org/0000-0003-1429-5818
Andy Peng XiangCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, China.ORCID https://orcid.org/0000-0003-3409-5012

Funding

National Natural Science Foundation of China 31771616National Natural Science Foundation of China 81730005National Natural Science Foundation of China 81970109the Key Scientific and Technological Program of Guangzhou City 201803040011the Key Scientific and Technological Projects of Guangdong Province 2019B020234001the Key Scientific and Technological Projects of Guangdong Province 2019B020235002the Key Scientific and Technological Projects of Guangdong Province 2019B020236004the National Key Research and Development Program of China, Stem Cell and Translational Research 2017YFA0105501the National Key Research and Development Program of China, Stem Cell and Translational Research 2018YFA0107203the National Key Research and Development Program of China, Stem Cell and Translational Research 2018YFA0108400the National Key Research and Development Program of China, Stem Cell and Translational Research 2018YFE0204400The National Key Research and Development Program of China, Stem Cell and Translational Research 2017YFA0105501The National Key Research and Development Program of China, Stem Cell and Translational Research 2018YFA0107203The National Key Research and Development Program of China, Stem Cell and Translational Research 2018YFA0108400The National Key Research and Development Program of China, Stem Cell and Translational Research 2018YFE0204400the National Natural Science Foundation of China 31771616the National Natural Science Foundation of China 81730005the National Natural Science Foundation of China 81970109The Strategic Priority Research Program of the Chinese Academy of Sciences XDA16040501The Strategic Priority Research Program of the Chinese Academy of Sciences XDA16040502The Strategic Priority Research Program of the Chinese Academy of Sciences XDA16040504
6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) have attracted great interest for cell therapy and tissue regeneration due to their self-renewal capacity, multipotency and potent immunomodulatory effects on immune cells. However, heterogeneity of MSCs has become a prominent obstacle to limit their translation into practice, as cells from different tissue sources or each individual have great differences in their transcriptomic signatures, differentiation potential and biological functions. Therefore, there is an urgent need for consensus standard for the quality control and technical specifications of MSCs. 'Human Mesenchymal Stem Cells' is the latest set of guidelines on hMSC in China, jointly drafted and agreed upon by experts from the Chinese Society for Stem Cell Research. This standard specifies the technical requirements, test methods, test regulations, instructions for use, labelling requirements, packaging requirements, storage requirements, transportation requirements and waste disposal requirements for hMSC, which is applicable to the quality control for hMSC. It was originally released by the China Society for Cell Biology on 9 January 2021. We hope that publication of these guidelines will facilitate institutional establishment, acceptance and execution of proper protocols, and accelerate the international standardization of hMSC for clinical development and therapeutic applications.

Indexed as

Mesenchymal Stem CellsMesenchymal Stem Cell TransplantationCell- and Tissue-Based TherapyCell DifferentiationChinaHumansImmunomodulation

Identifiers

PMID34936710
PMCPMC9055891

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.