Evidence map›Paper›PMID 34936462›Full record

ArticleScience advances2021

Cryo-EM structure of the autoinhibited state of myosin-2.

Sarah M Heissler, Amandeep S Arora, Neil Billington, James R Sellers, Krishna Chinthalapudi

Abstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Smooth muscle contractile cytoskeleton in health and disease.Journal of muscle research and cell motility · 2026
    Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Structural basis of nonmuscle myosin-2 autoinhibition mechanisms.bioRxiv : the preprint server for biology · 2025
    Article
  13. Myosin 2 - A general contractor for the cytoskeleton.Current opinion in cell biology · 2025
    Review
  14. Review
  15. Review
  16. Structure, regulation, and mechanisms of nonmuscle myosin-2.Cellular and molecular life sciences : CMLS · 2024
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sarah M HeisslerDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, OH, USA.ORCID 0000-0002-6972-7940
Amandeep S AroraDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, OH, USA.
Neil BillingtonLaboratory of Molecular Physiology, National Heart, Lung, and Blood Institute, Bethesda, MD, USA.ORCID 0000-0003-2306-0228
James R SellersLaboratory of Molecular Physiology, National Heart, Lung, and Blood Institute, Bethesda, MD, USA.
Krishna ChinthalapudiDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, OH, USA.ORCID 0000-0003-3669-561X

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
Structure and function of nonmuscle myosinsR01GM143539 · NIGMS · OHIO STATE UNIVERSITY · PI CHINTHALAPUDI, KRISHNA · 2021 to 2025
$2.1M
ROLE OF PHOSPHORYLATION AS A REGULATORY MECHANISM IN MUSCLE CONTRACTIONZ01HL001786 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI SELLERS, JAMES R. · 1985 to 2008
$601k
Intramural NIH HHS Z01 HL001786NCI NIH HHS P30 CA016058NIGMS NIH HHS R01 GM143539
6 · The paper itself

Abstract

We solved the near-atomic resolution structure of smooth muscle myosin-2 in the autoinhibited state (10

Identifiers

PMID34936462
PMCPMC8694606

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.